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折扣/货期| 货号：11539 | 规格：1 ea | 目录价：￥4270 |
产品详情
产品名称:
Thioredoxin 1 (human) Monoclonal Antibody (Clone 2G11)
别名:
Trx1|Txn1
产品描述:
Thioredoxin 1 (Trx1) is a thiol-disulfide oxidoreductase and part of the antioxidant thioredoxin system that is involved in the maintenance of cellular thiol redox homeostasis.{57135,57136,57138} It is ubiquitously expressed, localizes primarily to the cytoplasm with some nuclear localization, and is upregulated in and released from cells under conditions of oxidative stress.{57135,57136,57137} Trx1 contains two active site cysteine residues at positions 32 and 35, with additional cysteines at positions 62, 69, and 73.{57136} During the catalytic cycle, the active site cysteines are oxidized to a disulfide upon reduction of oxidized protein disulfide substrates and are subsequently restored to their reduced state by thioredoxin reductase (TrxR) and NADPH.{57135,57136} It regulates redox-sensitive transcription factors including NF-κB, p53, and the glucocorticoid receptor, as well as inhibits apoptosis through redox-sensitive binding and regulation of apoptosis signal-regulating kinase 1 (ASK1).{57136,57137} Exogenous administration of extracellular recombinant human Trx1 has anti-inflammatory effects in a variety of animal models.{57136} Trx1 levels are increased in a variety of human primary tumors, and increased tumor levels of Trx1 are associated with decreased survival in patients with colorectal cancer.{57137} Cayman's Thioredoxin 1 (human) Monoclonal Antibody (Clone 2G11) can be used for ELISA, immunofluorescence (IF), immunoprecipitation (IP), and Western blot (WB) applications.
宿主来源:
Mouse
实验应用:
ELISA, IF, IP, WB
同种型:
IgG1
免疫原:
Human Trx1
克隆号:
2G11
保存温度:
-20
运输温度:
-20
产品形式:
110 μg of affinity-purified monoclonal antibody
有效期:
1095
来源:
Animal/Mouse
上一个:HMGB1 Monoclonal Antibody (Clone IMG19N12A1)
下一个:Thioredoxin 1 Truncated (human) Monoclonal Antibody (Clone 7D11)
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