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折扣/货期| 货号：37448-1 mg | 规格：1 mg | 目录价：￥364 |
| 货号：37448-10 mg | 规格：10 mg | 目录价：￥2856 |
| 货号：37448-25 mg | 规格：25 mg | 目录价：￥6258 |
| 货号：37448-5 mg | 规格：5 mg | 目录价：￥1624 |
产品详情
产品名称:
Tat-CBD3 (trifluoroacetate salt)
产品描述:
Tat-CBD3 is an inhibitor of the protein-protein interaction between the N-type voltage-gated calcium channel Cav2.2 and collapsin response mediator protein 2 (CRMP2).{68533,64987} It also inhibits the protein-protein interaction between CRMP2 and the NMDA receptor NR2B subunit.{68534} Tat-CBD3 (10 µM) inhibits the Cav2.2-CRMP2 interaction by 43% in a cell-free assay and the NMDA receptor NR2B subunit-CRMP2 interaction in an immunoprecipitation assay.{64987,68534} It reduces voltage-induced calcium currents by approximately 60% in primary rat dorsal root ganglion (DRG) neurons and glutamate-induced increases in cytosolic calcium levels in primary rat hippocampal neurons.{68533,68534} Tat-CBD3 (20 mg/kg) decreases infarct volume in a rat model of cerebral ischemia induced by middle cerebral artery occlusion (MCAO).{68535} Intrathecal administration of Tat-CBD3 (20 µg/5 µl) prevents carrageenan-induced thermal hypersensitivity in rats.{64987}
保存温度:
-20
运输温度:
-20
预期分子量:
3192.7
产品形式:
A solid
有效期:
1460
纯度:
≥95%
分子式:
C134H243N59O32 • XCF3COOH
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