官网链接
折扣/货期| 货号：23593 | 规格：100 µg | 目录价：￥8260 |
产品详情
产品名称:
STING R224 variant (human, recombinant)
别名:
Endoplasmic Reticulum Interferon Stimulator|Stimulator of Interferon Genes|TMEM173
产品描述:
STING R224 variant (human, recombinant) contains amino acids 138-379 of the wild-type variant (R232) with lysine 224 substituted with arginine. Stimulator of interferon genes (STING) is a component of the innate immune response that binds to cyclic dinucleotides, which are bacterial second messengers, leading to activation of NF-κB and transcription of immunomodulatory genes, including type I interferon (IFN).{22400,22401,24611,24607} The R232 variant of STING is the most common variant in the human population, found at a frequency of 57.9% in the 1000 Genome Project.{38697} The SNP variant H232 is found at a 13.7% frequency. The K224R mutation prevents ubiquitination of STING at position K224, a process which is essential for efficient cytosolic DNA-mediated signaling.{34537} Therefore, this mutation disrupts optimal STING trafficking, which inhibits TBK1-mediated IRF3 activation but not NF-κB activation.
保存温度:
-80
运输温度:
-80
产品形式:
50 mM HEPES, pH 8.0, with 150 mM sodium chloride, and 10% glycerol
有效期:
730
纯度:
≥70% estimated by SDS-PAGE
您可能感兴趣的产品
Human Aldolase C protein
货号：GTX67212-pro
Human Sorbitol Dehydrogenase protein (active)
货号：GTX67160-pro
Human Fumarate hydratase protein (active)
货号：GTX66998-pro
beta Galactosidase protein
货号：GTX04676-pro
Human Lysozyme protein (active)
货号：GTX03701-pro
Human Flavin reductase protein
货号：GTX67254-pro
Human Aspartoacylase protein
货号：GTX67242-pro
Human Aldolase C protein (active)
货号：GTX66923-pro
促销活动
