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折扣/货期| 货号：10318 | 规格：100 µg | 目录价：￥6720 |
产品详情
产品名称:
SIRT5 (human, recombinant)
别名:
Mitochondrial Regulatory Protein SIR2 Homolog 5|NAD-dependent Deacetylase 5|NAD-dependent Protein Deacylase Sirtuin-5|Silent Information Regulator 5|SIR2-like Protein 5|SIR2L5|Sirtuin 5
产品描述:
Sirtuin 5 (SIRT5) is an enzyme that catalyzes the NAD-dependent removal of malonyl, succinyl, and glutaryl groups from target proteins.{55107,55108} Although it was originally characterized as a class III histone deacetylase (HDAC), SIRT5 exhibits weak NAD-dependent deacetylase activity in vitro and in vivo. SIRT5 is localized to mitochondria and is composed of a zinc binding domain and a Rossmann fold domain with the NAD and substrate binding sites located at the domain interface.{55107} Knockdown of Sirt5 induces hepatic and muscle protein hypersuccinylation, as well as fatty acid oxidation defects and hypertrophic cardiomyopathy in mice.{55109} SIRT5 protein and mRNA expression is elevated in human non-small cell lung cancer (NSCLC) tumors and is predictive of tumor recurrence and poor survival.{55110} SIRT5 also interacts with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) non-structural protein 14 (Nsp14), an exoribonuclease component of the viral replicase-transcriptase complex.{55024} Cayman’s SIRT5 (human, recombinant) protein can be used for ELISA and western blot applications.
保存温度:
-80
运输温度:
-80
产品形式:
50 mM NaPO4, pH 7.2, 100 mM sodium chloride, 5mM DTT, 20% glycerol
有效期:
730
纯度:
≥85% estimated by SDS-PAGE
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