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折扣/货期| 货号：450-44-100ug | 规格：100ug | 目录价：￥22138 |
| 货号：450-44-10ug | 规格：10ug | 目录价：￥2836 |
| 货号：450-44-1mg | 规格：1mg | 目录价：￥88652 |
| 货号：450-44-250ug | 规格：250ug | 目录价：￥38710 |
| 货号：450-44-2ug | 规格：2ug | 目录价：￥1163 |
| 货号：450-44-500ug | 规格：500ug | 目录价：￥57513 |
| 货号：450-44-50ug | 规格：50ug | 目录价：￥13268 |
产品详情
产品名称:
Recombinant Murine GDNF
别名:
Glial-Derived Neurotrophic Factor, ATF-1
产品描述:
GDNF is a disulfide-linked, homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRalpha (alpha1-alpha4) receptors. GDNF specifically promotes dopamine uptake and survival, and morphological differentiation of midbrain neurons. Using a Parkinson's disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. The functional murine GDNF ligand is a disulfide-linked homodimer consisting of two 15.1 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, including Cys-101, which is used for inter-chain disulfide bridging, and others that are involved in the intramolecular ring formation known as the cysteine-knot configuration. The calculated molecular weight of Recombinant Murine GDNF is 30.2 kDa.
宿主来源:
E.coli
推荐稀释度:
请严格按照批次特异性说明书中Reconstitution部分指定的溶液溶解蛋白到推荐浓度
预期分子量:
30.2 kDa
产品形式:
Bulk
产地:
美国
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