官网链接
折扣/货期| 货号：130-13-100ug | 规格：100ug | 目录价：￥15090 |
| 货号：130-13-1mg | 规格：1mg | 目录价：￥66806 |
| 货号：130-13-20ug | 规格：20ug | 目录价：￥2910 |
| 货号：130-13-250ug | 规格：250ug | 目录价：￥29185 |
| 货号：130-13-500ug | 规格：500ug | 目录价：￥43351 |
| 货号：130-13-5ug | 规格：5ug | 目录价：￥1169 |
产品详情
产品名称:
Recombinant Human PEDF
别名:
Pigment epithelium-derived factor, SerpinF1, EPC-1
产品描述:
PEDF is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties. It is a 50 kDa glycoprotein produced and secreted in many tissues throughout the body. A major component of the anti-angiogenic action of PEDF is the induction of apoptosis in proliferating endothelial cells. In addition, PEDF is able to inhibit the activity of angiogenic factors, such as VEGF and FGF-2. The neuroprotective effects of PEDF are achieved through suppression of neuronal apoptosis induced by peroxide, glutamate, or other neurotoxins. The recent identification of a lipase-linked cell membrane receptor for PEDF (PEDF-R) that binds to PEDF with high affinity (1) should facilitate further elucidation of the underlying mechanisms of this pluripotent serpin. To date, PEDF-R is the only signaling receptor known to be used by a serpin family member. The unique range of PEDF activities implicate it as a potential therapeutic agent for the treatment of vasculature-related neurodegenerative diseases, such as age-related macular degeneration (AMD) and proliferative diabetic retinopathy (PDR). PEDF also has the potential to be useful in the treatment of various angiogenesis-related diseases including a number of cancers. Recombinant Human PEDF is a 44.5 kDa non-glycosylated protein containing 400 amino acid residues. (1) Notari, I. et al. J Biol Chem., Vol. 281, 38022-38037.
宿主来源:
E.coli
推荐稀释度:
请严格按照批次特异性说明书中Reconstitution部分指定的溶液溶解蛋白到推荐浓度
预期分子量:
44.5 kDa
产品形式:
Bulk
产地:
美国
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