货号:140-04-100ug | 规格:100ug | 目录价:¥22246 |
货号:140-04-10ug | 规格:10ug | 目录价:¥2850 |
货号:140-04-1mg | 规格:1mg | 目录价:¥89085 |
货号:140-04-250ug | 规格:250ug | 目录价:¥38900 |
货号:140-04-2ug | 规格:2ug | 目录价:¥1169 |
货号:140-04-500ug | 规格:500ug | 目录价:¥57794 |
货号:140-04-50ug | 规格:50ug | 目录价:¥13333 |
产品详情
产品名称:
Recombinant Human PAI-1
别名:
Plasminogen Activator Inhibitor-1, Serpin E1
产品描述:
Plasminogen Activator Inhibitor-1 (PAI-1, Serpin E1) is a member of the serpin family of serine protease inhibitors, and is the primary inhibitor of urokinase and tissue plasminogen activator (tPA). PAI-1 is expressed predominantly in adipose, liver and vascular tissues, but is also produced by certain tumor cells. Elevated levels of PAI-1 are associated with obesity, diabetes and cardiovascular disease, and increased production of PAI-1 is induced by various obesity-related factors, such as TNFalpha, glucose, insulin, and very-low-density lipoprotein. The obesity-related elevation of PAI-1 levels, along with the consequential deficiency in plasminogen activators, can lead directly to increased risk of thrombosis and other coronary diseases. Accordingly, PAI-1 has been implicated as an important molecular link between obesity and coronary disease. PAI-1 can also specifically bind vitronectin (VTN) to form a stable active complex with an increased circulatory half-life relative to free PAI-1. Recombinant Human PAI-1 is a 42.7 kDa protein containing 379 amino acid residues.
宿主来源:
E.coli
推荐稀释度:
请严格按照批次特异性说明书中Reconstitution部分指定的溶液溶解蛋白到推荐浓度
预期分子量:
42.7 kDa
产品形式:
Bulk
产地:
美国
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