官网链接
折扣/货期| 货号：120-10C-100ug | 规格：100ug | 目录价：￥15290 |
| 货号：120-10C-1mg | 规格：1mg | 目录价：￥66482 |
| 货号：120-10C-20ug | 规格：20ug | 目录价：￥2900 |
| 货号：120-10C-250ug | 规格：250ug | 目录价：￥29043 |
| 货号：120-10C-500ug | 规格：500ug | 目录价：￥43140 |
| 货号：120-10C-50ug | 规格：50ug | 目录价：￥10170 |
| 货号：120-10C-5ug | 规格：5ug | 目录价：￥1163 |
产品详情
产品名称:
Recombinant Human Noggin
别名:
None
产品描述:
Noggin belongs to a group of diffusible proteins that bind to ligands of the TGF-beta family, and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-beta ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Noggin was originally identified as a BMP-4 antagonist whose action was critical for proper formation of the head and other dorsal structures. Consequently, noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of noggin in mice results in prenatal death, and a recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis. Recombinant Human Noggin is a 46 kDa disulfide-linked homodimer consisting of two 205 amino acid polypeptide chains. Monomeric glycosylated noggin migrates at an apparent molecular weight of approximately 28.0-33.0 kDa by SDS PAGE analysis under reducing conditions.
宿主来源:
HEK293 cells
推荐稀释度:
请严格按照批次特异性说明书中Reconstitution部分指定的溶液溶解蛋白到推荐浓度
预期分子量:
46 kDa
产品形式:
Bulk
产地:
美国
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