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Prostaglandin J2

品牌：Cayman

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说明书

折扣/货期

货号：18500-1 mg	规格：1 mg	目录价：￥2254
货号：18500-10 mg	规格：10 mg	目录价：￥16408
货号：18500-5 mg	规格：5 mg	目录价：￥9394
货号：18500-500 µg	规格：500 µg	目录价：￥1204

产品详情

产品名称:

Prostaglandin J2

别名:

PGJ2

产品描述:

Prostaglandin J2 (PGJ2) is a metabolite of PGD2 (Item No. 12010) and an agonist of the prostaglandin D2 (PGD2) receptor subtypes DP1 and DP2/CRTH.{9080,11291} It is formed from PGD2 by spontaneous dehydration.{58890} PGJ2 binds to DP1 and DP2/CRTH receptors (Kis = 0.9 and 6.6 nM, respectively) and either increases or inhibits the production of cAMP (EC50s = 1.2 and 13.1 nM, respectively, in HEK293 cells expressing the human receptors).{9080,11291} PGJ2 is neurotoxic and induces apoptosis, oxidative stress, and the accumulation of ubiquitinated proteins in the brain.{58891} It promotes the cleavage of amyloid precursor protein (APP) by α- and β-secretase in primary rat cerebral cortical neurons when used at a concentration of 10 µM.{58890} The levels of PGJ2 increase in the brain after stroke or traumatic brain injury (TBI) in rodents and it accumulates in the spinal cord of patients with sporadic amyotrophic lateral sclerosis (ALS).

保存温度:

-80

运输温度:

-80

预期分子量:

334.5

产品形式:

A solution in methyl acetate

有效期:

730

纯度:

≥95%