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折扣/货期| 货号：34053-1 mg | 规格：1 mg | 目录价：￥6104 |
| 货号：34053-500 µg | 规格：500 µg | 目录价：￥3234 |
产品详情
产品名称:
Plitidepsin
别名:
Aplidin|Dehydrodidemnin B
产品描述:
Plitidepsin is a depsipeptide that was originally isolated from Aplidium albicans and has diverse biological activities.{62362,62363,55470} It binds to the α subunit isoform eEF1A2 of eukaryotic elongation factor 1 (eEF1; Kd = 79 nM) and inhibits the proliferation of NCI H460 non-small cell lung cancer (NSCLC) and HGC-27 gastric cancer cells (IC50s = 0.2 and 0.9 nM, respectively).{62362} Plitidepsin (0.01 nM) inhibits bone resorption by osteoclasts in a pit formation assay using bovine bone slices.{62363} It reduces viral titers and lung inflammation in the K18-hACE2 mouse model of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection when administered at a dose of 0.3 mg/kg.{55470}
保存温度:
-20
运输温度:
-20
预期分子量:
1110.3
产品形式:
A solution in acetonitrile
有效期:
730
纯度:
≥98%
来源:
Synthetic
CAS号:
137219-37-5
分子式:
C57H87N7O15
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