货号:33878-1 mg | 规格:1 mg | 目录价:¥868 |
货号:33878-10 mg | 规格:10 mg | 目录价:¥5432 |
货号:33878-25 mg | 规格:25 mg | 目录价:¥11466 |
货号:33878-5 mg | 规格:5 mg | 目录价:¥3346 |
产品详情
产品名称:
Plecanatide (acetate)
别名:
SP-304
产品描述:
Plecanatide is a peptide agonist of the guanylate cyclase C receptor.{62429} It stimulates cGMP production in T84 colon cancer cells (EC50 = 170 nM). Plecanatide (10 ppm in the diet) reduces increases in the number of neoplastic colon epithelial cells expressing Ki-67, a marker of cell proliferation, induced by dextran sulfate (DSS; Item No. 23250) in cancer-prone Apc+/Min-FCCC mice.{62430} It suppresses trinitrobenzenesulfonic acid-induced increases in abdominal contractions in a rat model of visceral hypersensitivity when administered at doses of 0.01 and 0.05 mg/kg.{62431} Formulations containing plecanatide have been used in the treatment of chronic idiopathic constipation.
保存温度:
-20
运输温度:
-20
预期分子量:
1741.9
产品形式:
A solid
有效期:
1460
纯度:
≥98%
CAS号:
1075732-84-1
分子式:
C65H104N18O26S4 • C2H4O2
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