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折扣/货期| 货号：39986-1 mg | 规格：1 mg | 目录价：￥2366 |
| 货号：39986-5 mg | 规格：5 mg | 目录价：￥9352 |
| 货号：39986-500 µg | 规格：500 µg | 目录价：￥1246 |
产品详情
产品名称:
PE 22-28 (acetate)
别名:
Gly-Val-Ser-Trp-Gly-Leu-Arg-OH
产品描述:
PE 22-28 is a peptide inhibitor of the two-pore domain potassium channel K2P2.1/TREK1 (IC50 = 0.1 nM in HEK293 cells expressing the human channel) and a fragment of spadin (Item No. 36762).{72321} It is selective for K2P2.1/TREK1 over K2P10.1 /TREK2, K2P13.1/TRAAK, K2P18.1/TRESK, and K2P3.1/TASK1 in HEK293 cells expressing the human channels at 100 nM. PE 22-28 (4 µg/kg for four days) increases neurogenesis and the levels of postsynaptic density protein 95 (Psd-95), a measure of increased synaptogenesis, in isolated mouse hippocampi. It decreases immobility in the forced swim test, latency to feed in the novelty-suppressed feeding test, and the time to escape in the Porsolt learned helplessness test in mice when administered at a dose of 0.3 µg/kg for four days.
保存温度:
-20
运输温度:
-20
预期分子量:
773.9
产品形式:
A solid
有效期:
1460
纯度:
≥98%
分子式:
C35H55N11O9 • XC2H4O2
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