Pap12-6 (trifluoroacetate salt)-其他肽-ELISA_抗体_蛋白_核苷酸_试剂盒-深圳九游会j9网站首页有限公司

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Pap12-6 (trifluoroacetate salt)

品牌：Cayman

官网链接

说明书

折扣/货期

货号：37454-1 mg	规格：1 mg	目录价：￥364
货号：37454-10 mg	规格：10 mg	目录价：￥3220
货号：37454-25 mg	规格：25 mg	目录价：￥7588
货号：37454-5 mg	规格：5 mg	目录价：￥1708

产品详情

产品名称:

Pap12-6 (trifluoroacetate salt)

产品描述:

Pap12-6 is an antibacterial peptide derived from the twelve N-terminal amino acids of the peptide papiliocin, which has been found in P. xuthus larvae.{51476} It is active against a panel of eight Gram-negative bacteria, including E. coli, P. aeruginosa, and S. syphimurium (MIC50s = 4-8 µM), and the Gram-positive bacteria S. aureus, methicillin-resistant S. aureus 3126 (MRSA-3126), B. subtilis, and S. epidermidis (MIC50s = 4-8 µM) without affecting the viability of human erythrocytes, mouse RAW 264.7 macrophages, human HaCaT keratinocytes, or human HEK293 kidney cells at 25 µM. Pap12-6 induces membrane depolarization in E. coli when used at concentrations of 4 and 8 µM. Preincubation with Pap12-6 (10 µM) reduces nitrite (NO2-), Tnf-α, and Il-6 secretion levels in LPS-stimulated RAW 264.7 macrophages. In vivo, Pap12-6 (10 mg/kg) increases survival in mice infected with E. coli, as well as reduces the number of colony forming units (CFUs) in the lungs, liver, and kidneys in E. coli-infected mice when administered at a dose of 1 mg/kg. Pap12-6 (1 mg/kg) reduces serum aspartate aminotransferase (AST) and alanine transaminase (ALT) levels and blood urea nitrogen levels in a mouse model of E. coli-induced sepsis.

保存温度:

-20

运输温度:

-20

预期分子量:

1645.1

产品形式:

A solid

有效期:

1460

纯度:

≥95%