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折扣/货期| 货号：36910-1 mg | 规格：1 mg | 目录价：￥2128 |
| 货号：36910-10 mg | 规格：10 mg | 目录价：￥17024 |
| 货号：36910-25 mg | 规格：25 mg | 目录价：￥37254 |
| 货号：36910-5 mg | 规格：5 mg | 目录价：￥9590 |
产品详情
产品名称:
PAMP-12 (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)
别名:
PAMP (9-20)|Proadrenomedullin N-terminal 12 Peptide
产品描述:
Proadrenomedullin N-terminal 12 peptide (PAMP-12) is an endogenous peptide fragment found in the adrenal medulla that corresponds to amino acids 9-20 of human PAMP-20 and is involved in hypotension.{69443,42630,69444} It is an agonist of MAS-related G protein-coupled receptor family member X2 (MRGPRX2).{42630} PAMP-12 inhibits forskolin-induced cAMP accumulation in CHO cells expressing human MRGPRX2 (EC50 = 57.2 nM). It selectively induces calcium mobilization in CHO cells expressing MRGPRX2 (EC50 = 41 nM) over those expressing MRGPRX1, MRGPRX3, or MRGPRX4 at 1 µM. PAMP-12 is an antagonist of nicotinic acetylcholine receptors (nAChRs) that inhibits carbachol-induced catecholamine release (IC50 = 1.3 µM) and calcium and sodium influx (IC50s = 0.39 and 0.87 µM, respectively), but not histamine-induced catecholamine release or calcium and sodium influx (IC50s = >1 µM for all), in primary bovine adrenal chromaffin cells.{69444} It reduces mean arterial blood pressure in normotensive rats when administered at doses ranging from 10 to 50 nmol/kg.{69443}
保存温度:
-20
运输温度:
-20
预期分子量:
1618.9
产品形式:
A solid
有效期:
1460
纯度:
≥95%
分子式:
C77H119N25O14 • XCF3COOH
上一个:Bak BH3 (72-87) (human) (trifluoroacetate salt)
下一个:Exendin-4 (3-39) amide (trifluoroacetate salt)
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