PAD4 Monoclonal Antibody (Clone 11F9)-单抗-ELISA_抗体_蛋白_核苷酸_试剂盒-深圳九游会j9网站首页有限公司

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PAD4 Monoclonal Antibody (Clone 11F9)

品牌：Cayman

官网链接

说明书

折扣/货期

货号：19671

规格：100 µg

目录价：￥5600

产品详情

产品名称:

PAD4 Monoclonal Antibody (Clone 11F9)

别名:

HL-60 PAD|PADI4|Peptidylarginine Deiminase IV|Protein-arginine Deiminase type-4

产品描述:

Protein arginine deiminase 4 (PAD4) catalyzes the conversion of arginine residues to citrulline within cellular protein substrates, resulting in the loss of a positive charge, which can alter protein structure and/or function.{45610} It is expressed in neutrophils, as well as a variety of tissues, including the brain, liver, lung, and kidney.{45610,45611,18134} PAD4 has a key role in NETosis, a lytic form of cell death characterized by the release of neutrophil extracellular traps (NETs).{45610} Upon neutrophil activation, PAD4 translocates to the nucleus where it citrullinates histones, initiating chromatin decondensation and the release of NETs.{45611,19778,61223} Neutrophils isolated from Pad4-/- mice exhibit decreased citrullination of histone H3 under both basal and LPS-stimulated conditions and are defective for NET formation in response to stimulation with LPS, phorbol 12-myristate 13-acetate (PMA; Item No. 10008014), or hydrogen peroxide.{19778} Pad4-/- mice exhibit larger lesions than wild-type mice in a model of necrotizing fasciitis induced by M1 group A S. pyogenes lacking the extracellular DNase Sda1. Pad4-deficient mice also exhibit reduced infarct size in a model of myocardial ischemia-reperfusion injury and reduced tumor growth in a Lewis lung carcinoma model.{45612,45611} Serum PAD4 autoantibodies have been found in patients with rheumatoid arthritis and are associated with disease severity.{19300} Cayman’s PAD4 Monoclonal Antibody (Clone 11F9) can be used for ELISA and Western blot (WB) applications. The antibody recognizes PAD4 at 74 kDa from human samples.

宿主来源:

Mouse

实验应用:

ELISA, WB

同种型:

IgG1

免疫原:

Full length recombinant PAD4 protein

克隆号:

11F9

保存温度:

-20