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Obeldesivir

品牌：Cayman

官网链接

说明书

折扣/货期

货号：40404-1 mg	规格：1 mg	目录价：￥910
货号：40404-10 mg	规格：10 mg	目录价：￥6370
货号：40404-25 mg	规格：25 mg	目录价：￥11382
货号：40404-5 mg	规格：5 mg	目录价：￥4102

产品详情

产品名称:

Obeldesivir

别名:

ATV006|GS-5245

产品描述:

Obeldesivir is an antiviral nucleoside analog and a prodrug form of GS-441524 (Item No. 30469).{72268} It inhibits the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and SARS-CoV-2 Βeta, Gamma, or Omicron variants in infected Vero E6 cells (EC50s = 1.36, 1.127, 0.349, and 0.106 µM, respectively) with a 50% cytotoxicity concentration (CC50) value of 128 µM. Obeldesivir (250 or 500 mg/kg per day) reduces nucleocapsid guide RNA (gRNA) copy number and small-guide RNA (sgRNA) levels in the lungs of, and decreases lung damage in, a KI-hACE2 mouse model of SARS-CoV-2 infection. It reduces the levels of the spike glycoprotein (S protein), also known as the surface glycoprotein, in the lungs of, as well as decreases particle forming units (PFUs) in the lung tissues, reduces lung and spleen inflammation, and prevents viral infection-induced death in, a K18-hACE2 mouse model of SARS-CoV-2 infection when administered at doses of 100 or 250 mg/kg per day.

保存温度:

-20

运输温度:

-20

预期分子量:

361.4

产品形式:

A solid

有效期:

1460

纯度:

≥98%