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折扣/货期| 货号：189542-200 µg | 规格：200 µg | 目录价：￥5096 |
| 货号：189542-50 µg | 规格：50 µg | 目录价：￥2142 |
产品详情
产品名称:
Nitrotyrosine Monoclonal Antibody (Clone CC.22.8C7.3)
别名:
3-Nitrotyrosine|NT
产品描述:
Nitrotyrosine is a post-translational modification that is formed by the nitration of tyrosine.{60009} Under conditions of oxidative stress, tyrosine is oxidized by reactive oxygen species (ROS) or, in the presence of hydrogen peroxide and nitrite, by myeloperoxidase (MPO) to yield a tyrosine radical that reacts with reactive nitrogen species (RNS), such as nitric oxide or peroxynitrite, to form nitrotyrosine. It exists in a free or protein-bound form and is commonly used as a marker of nitrosative or oxidative stress.{31710} Nitrotyrosine residues have been found in a variety of proteins, including LDL, surfactant protein A, angiotensin II, and human and bovine serum albumin.{60010} Free nitrotyrosine production induced by peroxynitrite is inhibited by the polyphenols epicatechin gallate, gallic acid, catechin, or epicatechin in cell-free assays, as well as in aortic rings isolated from normotensive and spontaneously hypertensive rats administered the antioxidant N-acetyl-cysteine (NAC; Item No. 20261).{60011,60012} Nitrotyrosine levels are increased in the affected tissues of numerous pathological conditions, including atherosclerosis, cancer, ulcerative colitis, Alzheimer's disease, and Parkinson's disease.{60010} Autoantibodies that recognize nitrotyrosinated proteins are increased in the synovium of patients with rheumatoid arthritis and are positively correlated with joint and tendon inflammation.{60009} Cayman's Nitrotyrosine Monoclonal Antibody (Clone CC.22.8C7.3) can be used for ELISA and Western blot (WB) applications.
宿主来源:
Mouse
实验应用:
ELISA, WB
同种型:
IgG2b
免疫原:
Peroxynitrite-treated KLH
克隆号:
CC.22.8C7.3
保存温度:
-20
运输温度:
-20
产品形式:
50 µg or 200 µg of protein G-purified antibody
有效期:
1095
来源:
Animal/Mouse
上一个:Rat Anti-TIM-3 IgG conjugated to R-Phycoerythrin
下一个:Prion Protein Monoclonal Antibody (Clone 12F10)
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