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Myeloperoxidase Monoclonal Antibody (Clone 5F6)
货号：15640 规格：1 ea (200 µg) 目录价：￥4410
产品详情
产品名称:
Myeloperoxidase Monoclonal Antibody (Clone 5F6)
别名:
MPO
产品描述:
Myeloperoxidase (MPO) is a heme-containing enzyme and the most abundant protein in polymorphonuclear leukocytes (PMNs).{57128} It is comprised of two subunits linked by a disulfide bridge with each subunit containing a light and a heavy polypeptide chain. It can oxidize a variety of substrates and catalyzes the formation of highly reactive (pseudo)hypohalous acids and radicals, including hypochlorous acid. MPO is stored in azurophilic granules of PMNs and is released from activated or necrotic PMNs, after which it can bind to and modify acidic serum proteins, as well as recruit additional PMNs. MPO also has roles in PMN apoptosis and antimicrobial defense systems, including neutrophil extracellular traps (NETs).{57128,23608,24590} MPO-deficient mice exhibit reduced survival in a polymicrobial sepsis model, increased susceptibility to experimental autoimmune encephalomyelitis (EAE), and increased atherosclerosis in mice also deficient in the LDL receptor and fed an atherogenic diet.{57128,57129,57127} Cayman's Myeloperoxidase Monoclonal Antibody (Clone 5F6) was developed by fusing the spleen of a non-immunized NZBWF1 mouse with a mouse myeloma cell line and can be used for immunofluorescence (IF) applications.
宿主来源:
Mouse
实验应用:
IF
同种型:
IgG2b
克隆号:
5F6
保存温度:
-20
运输温度:
-20
产品形式:
200 µg of affinity-purified monoclonal antibody
有效期:
1095
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