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折扣/货期| 货号：28258 | 规格：100 µg | 目录价：￥7644 |
产品详情
产品名称:
Metalloendopeptidase OMA1 (human, recombinant)
别名:
Metalloprotease-related Protein 1|MPRP-1|OMA1|Overlapping with the m-AAA Protease 1 Homolog
产品描述:
OMA1 is an ATP-independent metalloproteinase encoded by OMA1.{35969} It is localized to the mitochondrial inner membrane and is comprised of a matrix-facing N-terminal domain, a transmembrane domain, and a C-terminal M48 metallopeptidase domain that is exposed to the intermembrane space.{35969,35970} Under various stress conditions, including oxidative stress, heat stress, and mitochondrial membrane depolarization, OMA1 is activated and cleaves long isoforms of the GTPase optic atrophy 1 (OPA1) at the S1 cleavage site, leading to inhibition of mitochondrial fusion and increased mitochondrial fragmentation.{35969,35970,47769} Under stress conditions, OMA1 is also autocatalytically degraded, thereby limiting, and allowing for reversal of, the stress response.{35970,47769} Oma1-/- mouse embryonic fibroblasts exhibit a loss of mitochondrial fragmentation upon exposure to hydrogen peroxide.{35970} Mice lacking Oma1 exhibit impaired thermogenesis, increased hepatic steatosis and serum triglyceride levels, and high-fat diet-induced obesity.{47770} Cayman’s Metalloendopeptidase OMA1 (human, recombinant) can be used for Western blot and ELISA applications.
保存温度:
-80
运输温度:
-80
产品形式:
50 mM Tris, pH 8.0, with 150 mM sodium chloride, 10% glycerol, 0.5 M L-arginine, and 2 μM zinc chloride
有效期:
365
纯度:
≥90%
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