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MERS-CoV Nucleocapsid Protein (recombinant)
货号：40878 规格：100 µg 目录价：￥8064
产品详情
产品名称:
MERS-CoV Nucleocapsid Protein (recombinant)
别名:
MERS-CoV N Protein|MERS-CoV Nucleoprotein
产品描述:
Middle East respiratory syndrome coronavirus (MERS-CoV) is an enveloped positive-stranded RNA virus, a member of the Betacoronavirus genus, and a causative agent of MERS, an acute respiratory disease that often leads to pneumonia and renal failure.{62983,62985} The MERS-CoV nucleocapsid protein is composed of an intrinsically disordered region (IDR), an N-terminal domain that binds RNA, a flexible linker containing serine and arginine phosphorylation sites, a C-terminal domain that also participates in RNA binding and is responsible for dimerization, and another IDR.{51720,62925} Coronavirus nucleocapsid proteins, including the MERS-CoV nucleocapsid protein, package the viral genome into a ribonucleoprotein (RNP) complex.{62925} In addition, the MERS-CoV nucleocapsid protein interacts with the ubiquitin ligase TRIM25 and inhibits the activation of retinoic acid-inducible gene I (RIG-I) and phosphorylation of IFN regulatory factor 3 (IRF3) and NF-κB.{51721} It reduces IFN-β and IFN-λ1 promoter activity induced by the RIG-I caspase activation and recruitment domain (RIG-I-CARD), but not MDA5-CARD, and reduces Sendai virus-induced increases in IFN-β and IFN-λ1 mRNA levels. Cayman's MERS-CoV Nucleocapsid Protein (recombinant) consists of 424 amino acids and has a calculated molecular weight of 46.51 kDa.
宿主来源:
Insect cells
保存温度:
-80
运输温度:
-80
产品形式:
Lyophilized from sterile 20 mM Tris, pH 8.0, with 500 mM sodium chloride and 10% glycerol
有效期:
365
纯度:
≥90% as estimated by SDS-PAGE
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