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折扣/货期| 货号：40110 | 规格：100 µg | 目录价：￥6790 |
产品详情
产品名称:
Malate Dehydrogenase 1 (human, recombinant)
别名:
Aromatic α-keto Acid Reductase|Cytosolic Malate Dehydrogenase|MDH1|Mor2|Soluble Malate Dehydrogenase
产品描述:
Malate dehydrogenase 1 (MDH1) is an NAD-dependent dehydrogenase and oxidoreductase.{51751} It is composed of an N-terminal NAD binding domain and a C-terminal substrate binding domain that reversibly catalyzes the conversion of malate to oxaloacetate in the cytosol.{51751,51752} MDH1 functions as a homodimer and is ubiquitously expressed in the human body, functioning as a key metabolic enzyme in glycolysis and the urea acid cycle.{51751} MDH1 supports increased rates of cancer glycolysis by serving as both a carbon and NAD supplier in lieu of, and in addition to, lactate dehydrogenase (LDH).{51753} MDH1 expression is amplified in a variety of cancers, including lung squamous cell carcinoma, diffuse B cell lymphoma, as well as bladder and pancreatic cancers, and its higher expression is negatively correlated with patient survival. Oncogenic K-Ras-induced glycosylation of MDH1, but not the mitochondrial MDH2 isoform, stabilizes the substrate-binding domain, increases MDH1 activity, and increases proliferation in pancreatic cancer cells.{51754} MDH1 activity is increased in brain homogenates from patients with early Alzheimer’s disease compared to brain homogenates from age-matched individuals without Alzheimer's disease.{68420} Cayman’s Malate Dehydrogenase 1 (human, recombinant) protein can be used for ELISA, enzyme assay, and Western blot (WB) applications.
宿主来源:
E. coli
保存温度:
-80
运输温度:
-80
产品形式:
25 mM HEPES, pH 7.5, with 150 mM sodium chloride, 5% glycerol, and 1 mM mercaptoethanol
有效期:
365
纯度:
≥85% estimated by SDS-PAGE
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