官网链接
折扣/货期| 货号：CHI-MF-11135-C005 | 规格：5 ug | 目录价：￥3640 |
| 货号：CHI-MF-11135-C025 | 规格：25 ug | 目录价：￥9100 |
产品详情
产品名称:
IL-35 (mouse):Fc (human) (rec.)
别名:
Interleukin-35
产品描述:
Interleukin-35 (IL-35) is a novel IL-12 family cytokine produced by regulatory T cells (Treg) but not by resting or activated effector T cells (Teff). IL-35 is a heterodimeric protein composed of EBI3 (Epstein-Barr-Virus-induced gene 3) and IL-12a (p35). EBI3 is a downstream target of Foxp3, a transcription factor required for Treg-cell development and function, and thus Treg-cell restriction of IL35 occurs. Regulatory T cells are essential for maintaining self tolerance and preventing autoimmunity, and IL-35 is identified as a molecule that mediates the immune suppression function of Treg-cell. As an inhibitory cytokine, IL-35 induces proliferation of Treg-cell populations but suppresses Th17 cell development. Studies in mice show the absence of either IL-35 chain from Treg-cell reduces the cells' ability to suppress inflammation using an experimental model for inflammatory bowel disease. IL-35 is suggested as a potential target of immunotherapy. Recently, insufficient IL-35 levels were shown to play a pivotal role in the development of type 1 diabetes (T1D) and autoimmune diseases.
宿主来源:
CHO cells
保存温度:
-20°C
运输温度:
BLUE ICE
预期分子量:
~30-60kDa
产品形式:
solid
存储溶液:
Lyophilized from 0.2µm-filtered solution in PBS.
有效期:
Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
产地:
瑞士
纯度:
>95% (SDS-PAGE)
生物活性:
Bioactivity was measured in a cell proliferation assay of Con A activated mouse splenocytes.
内毒素水平:
<1EU/mg protein (LAL test; Lonza).
您可能感兴趣的产品
Human IL1F5 protein, His tag
货号：GTX68383-pro
Human VEGF165 protein, His tag
货号：GTX67937-pro
Rat IL6 protein, His tag (active)
货号：GTX67073-pro
Human IL6 protein, His tag (active)
货号：GTX67071-pro
Human IL2 protein (active)
货号：GTX67060-pro
Feline IL2 protein, His tag (active)
货号：GTX66898-pro
Human IL1 Receptor 1 protein, human IgG1 Fc tag (active)
货号：GTX65662-pro
Human IL1F10 protein, His tag
货号：GTX57238-pro
促销活动
精品推荐
相关产品推荐
IL-2 (mouse):Fc (mouse) (rec.) (non-lytic)
货号：CHI-MF-12002-C010
IL-4 (mouse):Fc (mouse) (rec.) (non-lytic)
货号：CHI-MF-12004-C010
IL-6 (mouse):Fc (mouse) (rec.) (non-lytic)
货号：CHI-MF-12006-C050
IL-10 (mouse):Fc (mouse) (rec.) (non-lytic)
货号：CHI-MF-12010-C010
IL-21 (mouse):Fc (mouse) (rec.) (non-lytic)
货号：CHI-MF-12021-C050
IL-21R (mouse):Fc (mouse) (rec.) (non-lytic)
货号：CHI-MF-12021R-C025
