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折扣/货期| 货号：AG-40B-0041-5010 | 规格：5 x 10 ug | 目录价：￥4680 |
| 货号：AG-40B-0041-C010 | 规格：10 ug | 目录价：￥1560 |
产品详情
产品名称:
IL-33 (mouse) (rec.) (untagged) MultiPack
别名:
Interleukin-33; IL-1F11; NF-HEV
产品描述:
Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released upon cell lysis. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1(MAPK3)/ERK2(MAPK1), p38(MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.
宿主来源:
E. coli
靶标/特异性:
Binds to mouse and human ST2.
产品浓度:
0.1mg/ml after reconstitution
保存温度:
-20°C
运输温度:
BLUE ICE
预期分子量:
~18kDa
产品形式:
solid
存储溶液:
Lyophilized. Contains PBS.
有效期:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
产地:
瑞士
纯度:
>95% (SDS-PAGE)
生物活性:
Activates ST2-dependent NF-kappaB pathway.
内毒素水平:
<0.1EU/µg purified protein (LAL test; Lonza).
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