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折扣/货期| 货号：CHI-HF-20102-C010 | 规格：10 ug | 目录价：￥2520 |
产品详情
产品名称:
IL-2 (C145S Mutant) (human) (rec.) (His)
别名:
Interleukin-2; Aldesleukin
产品描述:
Interleukin-2 (IL-2) is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells, and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils, and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta. Moreover, studies have shown that IL-2 is required for activation-induced apoptosis, an important hemeostatic mechanism in the immune system, which is involved in the maintenance of peripheral tolerance to self-antigens. The modified IL-2 protein containing a substitution at position C145S retains full biological activity, suggesting that the cysteine at this position is not involved in a disulfide bond and that a free sulfhydryl group at that position is not necessary for receptor binding. Additionally, the C145S mutation insertion avoids non-specific disulfides and improves the physical properties of the protein.
宿主来源:
HEK 293 cells
保存温度:
-20°C
运输温度:
BLUE ICE
预期分子量:
~19kDa (SDS-PAGE)
产品形式:
solid
存储溶液:
Lyophilized from 0.2µm-filtered solution in PBS.
有效期:
Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
产地:
瑞士
纯度:
>95% (SDS-PAGE)
生物活性:
Measured by its ability to stimulate the proliferation of mouse CTLL-2 cells. The ED50 for this effect is typically 0.1ng/mL, corresponding to a specific activity of 1x 107 units/mg.
内毒素水平:
<0.01EU/µg protein (LAL test; Lonza).
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