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折扣/货期| 货号：CHI-HR-20018-C010 | 规格：10 ug | 目录价：￥2030 |
| 货号：CHI-HR-20018-C050 | 规格：50 ug | 目录价：￥5740 |
产品详情
产品名称:
IL-18 (human) (rec.) (His)
别名:
Interleukin-18; Interferon-gamma-inducing Factor; IGIF; IL-1gamma; IL1F4
产品描述:
Interleukin-18 (IL-18) is a costimulatory factor for production of interferon-gamma (IFN-gamma) in response to toxic shock and shares functional similarities with IL-12. IL-18 is synthesized as a precursor 24kDa molecule without a signal peptide and must be cleaved to produce an active molecule. IL-1 converting enzyme (ICE; Caspase-1) cleaves pro-IL-18 at aspartic acid in the P1 position, producing the mature, bioactive peptide that is readily released from the cells. It is reported that IL-18 is produced from Kupffer cells, activated macrophages, keratinocytes, intestinal epithelial cells, osteoblasts, adrenal cortex cells and murine diencephalon. IFN-gamma is produced by activated T or NK cells and plays critical roles in the defense against microbiral pathogens. IFN-gamma activates macrophages and enhances NK activity and B cell maturation, proliferation and Ig secretion. IFN-gamma also induces expression of MHC class I and II antigens and inhibits osteoclast activation. IL-18 acts on T helper type-1 (Th1) T cells and in combination with IL-12 strongly induces them to produce IFN-gamma. Pleiotropic effects of IL-18 have also been reported, such as enhancement production of IFN-gamma and GM-CSF in peripheral blood mononuclear cells, production of Th1 cytokines, IL-2, GM-CSF, IFN-gamma in T cells and enhancement of Fas ligand expression by Th1 cells.
宿主来源:
E. coli
保存温度:
-20°C
运输温度:
BLUE ICE
预期分子量:
~20kDa (SDS-PAGE, reducing conditions)
产品形式:
solid
存储溶液:
Lyophilized from 0.2µm-filtered solution in 1X PBS.
有效期:
Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
产地:
瑞士
纯度:
>97% (SDS-PAGE)
内毒素水平:
<0.1EU/µg protein (LAL test; Lonza).
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