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Human caspase 8 protein, His tag
品牌：GeneTex
货号：GTX04107-pro 规格：50μg 目录价：￥7000
产品详情
产品名称:
Human caspase 8 protein, His tag
别名:
caspase 8 , ALPS2B , CAP4 , Casp-8 , FLICE , MACH , MCH5
克隆号:
偶联:
Unconjugated
产品浓度:
表达系统:
E.coli
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
22.8
产品形式:
Lyophilized powder
存储溶液:
Batch dependent (please contact us for details)
产地:
美国
功能与背景:
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]
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