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    Human Calmodulin protein
    品牌:GeneTex
    货号:GTX67262-pro 规格:100μg 目录价:¥4100
    产品详情
    产品名称:
    Human Calmodulin protein
    别名:
    calmodulin 2 , CALM , CALML2 , CAM1 , CAM3 , CAMC , CAMII , CAMIII , LQT15 , PHKD , PHKD2 , caM
    克隆号:
    偶联:
    Unconjugated
    产品浓度:
    1 mg/ml (Please refer to the vial label for the specific concentration.)
    表达系统:
    E. coli
    保存温度:
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
    运输温度:
    dry ice
    产品形式:
    Liquid
    存储溶液:
    20mM Tris-HCl, no preservative.
    产地:
    美国
    功能与背景:
    This gene is a member of the calmodulin gene family. There are three distinct calmodulin genes dispersed throughout the genome that encode the identical protein, but differ at the nucleotide level. Calmodulin is a calcium binding protein that plays a role in signaling pathways, cell cycle progression and proliferation. Several infants with severe forms of long-QT syndrome (LQTS) who displayed life-threatening ventricular arrhythmias together with delayed neurodevelopment and epilepsy were found to have mutations in either this gene or another member of the calmodulin gene family (PMID:23388215). Mutations in this gene have also been identified in patients with less severe forms of LQTS (PMID:24917665), while mutations in another calmodulin gene family member have been associated with catecholaminergic polymorphic ventricular tachycardia (CPVT)(PMID:23040497), a rare disorder thought to be the cause of a significant fraction of sudden cardiac deaths in young individuals. Pseudogenes of this gene are found on chromosomes 10, 13, and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
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