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折扣/货期| 货号：10009652 | 规格：10 µg | 目录价：￥9108 |
产品详情
产品名称:
HDAC4 (human, recombinant)
别名:
Histone Deacetylase 4
产品描述:
Histone deacetylase 4 (HDAC4) is a zinc-dependent metalloenzyme and class IIa HDAC.{22864} It is composed of an N-terminal regulatory domain, which contains a myocyte-specific enhancer factor 2 (MEF2) binding site, three 14-3-3 binding sites, a nuclear localization signal, and a caspase-3 cleavage site, a catalytic domain, and a C-terminal domain that contains a nuclear export signal. HDAC4 shuttles between the cytoplasm and nucleus and is mainly expressed in skeletal muscle, brain, ovaries, and colon but is also found in the small intestine, heart, kidney, testis, thymus, and leukocytes.{22634,64895} It acts as a transcriptional corepressor and has many binding partners, including the transcription factors MEF2 and RUNX family transcription factor 2 (RUNX2).{22864,64896} Knockout of Hdac4 induces premature ossification and chondrocyte hypertrophy in mice.{64896} Mutations in HDAC4 are associated with brachydactyly-mental retardation syndrome, a disorder characterized by brachydactyly type E, intellectual disability, and facial dysmorphisms.{64897} Cayman’s HDAC4 (human, recombinant) protein can be used for enzyme activity assays.
保存温度:
-80
运输温度:
-80
产品形式:
45 mM Tris-HCl, pH 8.0, with 124 mM sodium chloride, 2.4 mM potassium chloride, 18 mM glutathione, and 10% glycerol
有效期:
180
纯度:
≥60% estimated by SDS-PAGE
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