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折扣/货期| 货号：38846-1 mg | 规格：1 mg | 目录价：￥392 |
| 货号：38846-10 mg | 规格：10 mg | 目录价：￥3528 |
| 货号：38846-25 mg | 规格：25 mg | 目录价：￥6860 |
| 货号：38846-5 mg | 规格：5 mg | 目录价：￥1862 |
产品详情
产品名称:
EGFRvIII Peptide (trifluoroacetate salt)
别名:
Epidermal Growth Factor Receptor Variant III Peptide|PEGFRvIII (9-mer)
产品描述:
EGFRvIII peptide is a synthetic peptide that corresponds to the fusion junction of EGFRvIII, a tumor-specific, constitutively active variant of EGFR that lacks amino acids 6-273 of wild-type EGFR.{66481,66482} It binds to MHC class I subtype HLA-A*0201-positive T2 cells when used at a concentration of 25 µg/ml.{66481} EGFRvIII peptide induces antigen presentation in dendritic cells derived from isolated human peripheral blood mononuclear cells (PBMCs), which stimulates activation of, and IFN-γ production by, CD8+ cytotoxic T lymphocytes. Immunization with EGFRvIII peptide (15 µg/animal), in combination with the toll-like receptor 5 (TLR5) agonist flagellin B, increases the number of CD8+ T cells and decreases the number of regulatory T cells (Tregs) in the brain, reduces tumor volume, and increases survival rate in an orthotopic GL261 glioblastoma mouse xenograft model.{66482}
保存温度:
-20
运输温度:
-20
预期分子量:
1079.2
产品形式:
A solid
有效期:
1460
纯度:
≥98%
分子式:
C48H78N12O16 • XCF3COOH
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