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折扣/货期| 货号：SKT-120-96S | 规格：96 well | 目录价：￥5926.5 |
产品详情
产品名称:
DNA Damage (8-OHdG) ELISA Kit
别名:
8-OH-dG ELISA Kit, 8OHG ELISA Kit, 80G ELISA Kit, 8 hydroxyguanine ELISA Kit, 8-OHdG ELISA Kit, DNA Damage ELISA Kit
产品描述:
Colorimetric detection of 8-hydroxy-2-deoxy Guanosine
反应种属:
Species Independent
保存温度:
4ºC and -20ºC
运输温度:
Blue Ice
产地:
加拿大
功能与背景:
8-hydroxy-2-deoxy Guanosine (8-OH-dG) is produced by the oxidative damage of DNA by reactive oxygen and nitrogen species and serves as an established marker of oxidative stress (1-4). Hydroxylation of guanosine occurs in response to both normal metabolic processes and a variety of environmental factors (i.e., anything that increases reactive oxygen and nitrogen species). Increased levels of 8-OH-dG are associated with the aging process as well as with a number of pathological conditions including cancer, diabetes, and hypertension(5-9). In complex samples such as plasma, cell lysates, and tissues, 8-OH-dG can exist as either the free nucleoside or incorporated in DNA. Once the blood enters the kidney, free 8-OH-dG is readily filtered into the urine, while larger DNA fragments remain in the bloodstream. Because of the complexity of plasma samples, urine is a more suitable matrix for the measurement of free 8-OH-dG than plasma. Urinary levels of 8-OH-dG range between 2.7-13 ng/mg creatine, while plasma levels of free 8-OH-dG have been reported to be between 4-21 pg/ml as determined by LC-MS (10-11).
灵敏度:
0.59 ng/mL
检测范围:
0.94 - 60 ng/mL
检测方法:
Competitive
样本类型:
Urine | Cell Lysates | Plasma | Sample matrices
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