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折扣/货期| 货号：18356 | 规格：5 Kunits | 目录价：￥11480 |
产品详情
产品名称:
COX-2 (ovine, recombinant)
别名:
Cyclooxygenase 2|Inducible Cyclooxygenase Prostaglandin H Synthase 2
产品描述:
Cyclooxygenase 2 (COX-2) is a bifunctional enzyme that exhibits both COX and peroxidase activities and catalyzes the first step in the biosesynthesis of prostaglandins, thromboxanes, and prostacyclins.{500,501} The COX component converts arachidonic acid to the hydroperoxy endoperoxide prostaglandin G2 (PGG2; Item No. 17010), and the peroxidase component reduces the endoperoxide to the corresponding alcohol PGH2 (Item No. 17020). COX2 expression is induced by a variety of stimuli, including phorbol esters, LPS, and cytokines and is responsible for the biosesynthesis of PGs under acute inflammatory conditions.{54420,14766} Thus, COX-2 has been the focus of attention for nonsteroidal anti-inflammatory drug (NSAID) development. Cayman’s COX-2 (ovine, recombinant) protein can be used for enzyme activity assays.
保存温度:
-80
运输温度:
-80
有效期:
180
纯度:
≥80% estimated by SDS-PAGE
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