货号:160110 | 规格:1 ea (500 µg) | 目录价:¥4760 |
产品详情
产品名称:
COX-1 Monoclonal Antibody (Clone CX111)
别名:
Cyclooxygenase 1|PGHS-1|Prostaglandin Endoperoxide Synthase 1|Prostaglandin G/H Synthase 1|Prostaglandin H2 Synthase 1
产品描述:
Cyclooxygenase 1 (COX-1) is a bifunctional enzyme that exhibits both COX and peroxidase activities.{500,501} It is composed of an N-terminal signal peptide, an EGF-like domain, a membrane binding domain, a catalytic domain, and a C-terminal tail.{4376} COX-1 is constitutively expressed in the gastrointestinal tract, kidney, spleen, liver, and lung and localizes to the endoplasmic reticulum.{1299,1394} The COX component converts arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) to a hydroperoxyl endoperoxide prostaglandin G2 (PGG2; Item No. 17010) and the peroxidase component reduces the endoperoxide to the corresponding alcohol PGH2 (Item No. 17020), the precursor of PGs, thromboxanes, and prostacyclins.{500,501} COX-1 is the target of many non-steroidal anti-inflammatory drugs (NSAIDs) and is responsible for the undesirable gastrointestinal and renal side effects, such as ulcer formation and reductions in the glomerular filtration rate, respectively.{5282,4411} Cayman’s COX-1 Monoclonal Antibody (Clone CX111) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.
宿主来源:
Mouse
实验应用:
IHC, WB
同种型:
IgG2b
免疫原:
Purified ovine COX-1
克隆号:
CX111
保存温度:
-20
运输温度:
-20
产品形式:
500 µg of purified monoclonal antibody
有效期:
1095
来源:
Animal/Mouse
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