CCL5 (human) (rec.) (His)-细胞因子、趋化因子与生长因子-ELISA_抗体_蛋白_核苷酸

首页产品中心细胞因子、趋化因子与生长因子

CCL5 (human) (rec.) (His)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：CHI-HR-200CCL5-C050

规格：50 ug

目录价：￥7560

产品详情

产品名称:

CCL5 (human) (rec.) (His)

别名:

C-C Motif Chemokine 5; Eosinophil Chemotactic Cytokine; EoCP; Small-inducible Cytokine A5; T Cell-specific Protein P228; TCP228; T Cell-specific Protein RANTES

产品描述:

CCL5, also known as RANTES (Regulated upon Activation Normal T cell Expressed and Secreted), is an 8kDa beta-chemokine that plays a primary role in the inflammatory immune response by means of its ability to attract and activate leukocytes. Human and mouse RANTES exhibit cross-species activity on human and mouse cells. CCL5 is secreted by many cell types at inflammatory sites and it exerts a wide range of activities through the receptors CCR1, CCR3, CCR4 and CCR5. In humans, CCR5 binding to CCL5 inhibits the infectivity of R5 (M-tropic) but not X4 (T-tropic) strains of HIV-1. The deposition of CCL5 on activated vascular endothelial cells is crucial for monocyte adhesion to damaged vasculature, but CCL5 oligomerization is not required for the extravasation of adherent leukocytes. CCL5 is upregulated in breast cancer and promotes tumor progression through the attraction of proinflammatory macrophages in addition to its actions on tumor cells, stromal cells and the vasculature.

宿主来源:

E. coli

保存温度:

-20°C

运输温度:

BLUE ICE

产品形式:

solid

存储溶液:

Lyophilized from 0.2µm-filtered solution in PBS (pH 7.4).

有效期:

Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.