官网链接
折扣/货期| 货号：100029 | 规格：1 ea (500 µl) | 目录价：￥4410 |
产品详情
产品名称:
β-Catenin Polyclonal Antibody
别名:
Catenin (Cadherin-associated Protein), Beta 1|CTNNB1|EVR7|MRD19|NEDSDV
产品描述:
β-Catenin is a transcriptional coactivator that is encoded by the CTNNB1 gene in humans.{46678,11345} It is a 781 amino acid protein comprised of an N-terminal domain containing glycogen synthase kinase 3β (GSK3β) phosphorylation sites, a C-terminal transactivation domain, and a central domain spanning amino acid residues 138-664.{46679,46680} The central domain consists of 12 armadillo repeats and is required for binding to cadherins, TCF/LEF transcription factors, and adenomatous polyposis coli (APC). β-Catenin has roles in cell adhesion, canonical Wnt signaling, regulation of stem cells, embryonic development, and adult tissue homeostasis, among others.{46678,46679} In the absence of Wnt, a complex consisting of axin, APC, GSK3β, and casein kinase 1 (CK1), binds to and phosphorylates β-catenin, targeting it for ubiquitination and proteosomal degradation.{46678} In the presence of Wnt, phosphorylation of β-catenin is inhibited, allowing β-catenin to translocate into the nucleus, where it interacts with TCF/LEF to activate expression of Wnt target genes. Activating mutations in CTNNB1 that stabilize β-catenin have been associated with a variety of cancers, including hepatocellular and adrenocortical carcinomas, colorectal cancer, and pilomatricomas.{46681,46680,17947,26670} Cayman's β-Catenin Polyclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.
宿主来源:
Rabbit
实验应用:
IHC, WB
免疫原:
Synthetic peptide corresponding to the N-terminal region of human β-catenin
保存温度:
-20
运输温度:
-20
产品形式:
500 µl of peptide affinity-purified polyclonal antibody
有效期:
1095
来源:
Animal/Rabbit
促销活动
