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折扣/货期| 货号：360780 | 规格：200 µg | 目录价：￥1848 |
产品详情
产品名称:
Apaf-1 Blocking Peptide
产品描述:
Each vial contains 200 µg of lyophilized peptide corresponding to amino acids 12 to 28 of human Apaf-1.{6894} Apoptosis is related to many diseases and is induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. The mammalian homologues of the key cell death gene CED-4 in C. elegans has been identified recently from human and mouse and designated Apaf-1 (for apoptosis protease-activating factor 1).{6894,6873} Apaf-1 binds to cytochrome c (Apaf-2) and caspase-9 (Apaf-3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3, one of the key proteases responsible for the proteolytic cleavage of many key proteins in apoptosis.{6874} Apaf-1 can also associate with caspase-4 and caspase-8.{6878} Apaf-1 is ubiquitously expressed in human tissues.{6894}
保存温度:
-20
运输温度:
-20
产品形式:
A lyophilized peptide
有效期:
1095
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