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anti-IDO1 (human), mAb (ID 177)
品牌：Adipogen
货号：AG-20A-0035-C050 规格：50 ug 目录价：￥2160
货号：AG-20A-0035-C100 规格：100 ug 目录价：￥3000
产品详情
产品名称:
anti-IDO1 (human), mAb (ID 177)
别名:
Indoleamine 2,3-dioxygenase 1; IDO; INDO
产品描述:
IDO1 is a heme enzyme that catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway, causing depletion of tryptophan which can lead to halted growth of microbes as well as T cells. IDO1 is an immune checkpoint protein, thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation and antioxidant activity. Cancer cells are able to evade the immune system is by hijacking the checkpoint proteins. Increased IDO1 protein levels drive growth arrest and apoptosis of the effector T cells, a group of immune cells that mediate the immune system’s ability to destroy pathogens. By reducing the number of effector T cells, IDO1 overexpression prevents the immune system from effectively destroying cancer cells. IDO1 overexpression has been observed in a wide range of human cancers such as prostatic, colorectal, pancreatic, cervical, gastric, ovarian, head or lung cancer. Physiological IDO1 activity has been implicated in T cell tolerance to tumors, dysfunctional selftolerance in non-obese diabetic (NOD) mice, and as a protective negative regulator in autoimmune disorders.
实验应用:
ELISA, IHC, WB
靶标/特异性:
Recognizes human IDO1. Detects a band of ~45kDa by Western blot. Other species not tested.
同种型:
Mouse IgG1kappa
免疫原:
Recombinant human IDO1.
克隆号:
ID 177
产品浓度:
1mg/ml
保存温度:
-20°C
运输温度:
BLUE ICE
产品形式:
liquid
存储溶液:
Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives.
有效期:
Stable for at least 1 year after receipt when stored at -20°C.
产地:
瑞士
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