ALK4 Extracellular Domain (human, recombinant)-其他酶-ELISA_抗体_蛋白_核苷酸

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ALK4 Extracellular Domain (human, recombinant)

品牌：Cayman

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说明书

折扣/货期

货号：31846-1 mg	规格：1 mg	目录价：￥38358
货号：31846-100 µg	规格：100 µg	目录价：￥5904

产品详情

产品名称:

ALK4 Extracellular Domain (human, recombinant)

别名:

产品描述:

Activin receptor-like kinase 4 (ALK4) is a type I transmembrane glycoprotein, serine/threonine kinase, and member of the TGF-β superfamily that is encoded by ACVR1B in humans.{54900,54901} It is composed of an extracellular ligand-binding domain, a single transmembrane domain, an intracellular serine/threonine kinase domain, and a cytoplasmic serine/threonine-rich region. ALK4 is ubiquitously expressed and forms heterodimers with activin receptor type IIA (ACTRIIA) or ACTRIIB at the cell surface. Upon ligand activation by activin A, activin B, activin AB, or Nodal, ALK4 is phosphorylated by its heterodimer partner and induces intracellular signaling and phosphorylation of SMAD2 and SMAD3 to regulate gene expression. ALK4-mediated signaling has roles in glucose-stimulated insulin secretion, neuronal differentiation of pluripotent stem cells, and the development of pancreatic and pituitary cancers.{54900,54901,54902} Cayman's ALK4 Extracellular Domain (human, recombinant) protein can be used for binding assays. This protein consists of 114 amino acids, has a calculated molecular weight of 13 kDa, and a predicted N-terminus of Ser24 after signal peptide cleavage. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is 18-20 kDa due to glycosylation.

保存温度:

-80

运输温度:

-80

产品形式:

Lyophilized from sterile PBS, pH 7.4, with 5% trehalose and 5% mannitol

有效期:

365

纯度:

≥92% estimated by SDS-PAGE

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