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折扣/货期| 货号：14720-1 mg | 规格：1 mg | 目录价：￥1694 |
| 货号：14720-10 mg | 规格：10 mg | 目录价：￥12376 |
| 货号：14720-5 mg | 规格：5 mg | 目录价：￥7070 |
| 货号：14720-500 µg | 规格：500 µg | 目录价：￥910 |
产品详情
产品名称:
15-keto Prostaglandin E2
别名:
15-keto PGE2|15-oxo PGE2
产品描述:
15-keto Prostaglandin E2 (15-keto PGE2) is a metabolite of PGE2 (Item No. 14010) formed by 15-hydroxy prostaglandin dehydrogenase (15-PGDH).{2777} Unlike PGE2, 15-keto PGE2 does not bind effectively to the PGE2 receptors EP2 and EP4 expressed in CHO cells (Kis = 2.6 and 15 µM, respectively) or induce adenylate cyclase activity in the same cells (EC50s = 1.8 and >33 µM, respectively). However, it does bind to EP2 and EP4 in HEK cells expressing these receptors (IC50s = 0.117 and 2.82 µM, respectively), as well as induces cAMP formation (EC50s = 0.137 and 0.426 µM, respectively) and the transcriptional activity of β-catenin/TCF in the same cells.{57866} 15-keto PGE2 inhibits CD3-CD28-MHC-I-induced proliferation of isolated human CD4+ T cells in a concentration-dependent manner.{57867} It also reduces mortality in a mouse model of LPS-induced sepsis when administered at a dose of 15 mg/kg.{57868}
保存温度:
-20
运输温度:
-20
预期分子量:
350.5
产品形式:
A crystalline solid
有效期:
1460
纯度:
≥98%
CAS号:
26441-05-4
分子式:
C20H30O5
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