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13,14-dihydro-15-keto Prostaglandin E2
品牌:Cayman
货号:14650-1 mg 规格:1 mg 目录价:¥966
货号:14650-10 mg 规格:10 mg 目录价:¥8218
货号:14650-5 mg 规格:5 mg 目录价:¥4354
产品详情
产品名称:
13,14-dihydro-15-keto Prostaglandin E2
别名:
13,14-dihydro-15-keto PGE2|13,14-dihydro-oxo-PGE2|PGEM
产品描述:
13,14-dihydro-15-keto Prostaglandin E2 (13,14-dihydro-15-keto PGE2) is a metabolite of PGE2 (Item No. 14010) and the primary PGE2 metabolite in plasma.{182,2777} It is formed from PGE2 via a 15-keto PGE2 intermediate by 15-oxo-PG Δ13 reductase.{2777} Unlike PGE2, 13,14-dihydro-15-keto PGE2 does not bind effectively to the PGE2 receptors EP2 and EP4 expressed in CHO cells (Kis = 12 and 57 µM, respectively) or induce adenylate cyclase activity in the same cells (EC50s = >18 and >38 µM, respectively). Levels of 13,14-dihydro-15-keto PGE2 are increased in the plasma of women in the third trimester of pregnancy and in women during and immediately after labor and delivery.{64194} Levels of 13,14-dihydro-15-keto PGE2 levels are decreased in tumor tissue compared to adjacent non-cancerous tissue isolated from patients with non-small cell lung cancer (NSCLC).{64195}
保存温度:
-20
运输温度:
-20
预期分子量:
352.5
产品形式:
A solution in methyl acetate
有效期:
730
纯度:
≥95%
CAS号:
363-23-5
分子式:
C20H32O5
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