体内PD-1/PD-L信号阻断

(in vivo blocking of 

PD-1/PD-L signaling)

1. Wang, W., et al. (2018). 'RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in 

Pancreatic Cancer' Cancer Cell 34(5): 757-774 e757.

2. Gordon, S. R., et al. (2017). 'PD-1 expression by tumour-associated macrophages inhibits phagocytosis 

and tumour immunity' Nature 545(7655): 495-499.

3. Koyama, S., et al. (2016). 'STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory 

Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment' Cancer Res 76(5): 

999-1008.

体内PD-1/PD-L信号阻断，

流式细胞术

(in vivo blocking of 

PD-1/PD-L signaling, 

Flow Cytometry)

1.Koyama, S., et al. (2016). 'Adaptive resistance to therapeutic PD-1 blockade is associated with 

upregulation of alternative immune checkpoints' Nat Commun 7: 10501.

体外PD-1中和

（in vitro PD-1 neutralization）

1.Park, S. J., et al. (2014). 'Negative role of inducible PD-1 on survival of activated dendritic cells' J 

Leukoc Biol 95(4): 621-629.

流式细胞术

（Flow Cytometry）

1.Good-Jacobson, K. L., et al. (2012). 'CD80 expression on B cells regulates murine T follicular 

helper development, germinal center B cell survival, and plasma cell generation' J Immunol 188(9): 

4217-4225.

免疫荧光，蛋白质印迹

(Immunofluorescence, 

Western Blot)

1.Chen, L., et al. (2009). 'Role of the immune modulator programmed cell death-1 during development and 

apoptosis of mouse retinal ganglion cells' Invest Ophthalmol Vis Sci 50(10): 4941-4948.