醛固酮（Aldosterone）是一种由肾上腺皮质中的胆固醇合成的类固醇激素。醛固酮在肾脏和肝脏中代谢，并作为控制钠钾平衡的关键盐皮质激素发挥作用。肾上腺合成和释放醛固酮主要受肾素-血管紧张素-醛固酮系统（RAAS）的调节，RAAS主要作用是调节和维持血压、水电解质平衡和维持人体内环境稳态。检测血清醛固酮和血浆肾素在临床上用于区分原发性和继发性醛固酮增多症。原发性醛固酮增多症（醛固酮增多症）的特征是肾素与醛固酮比率非常低，导致钠滞留和血压升高，通常是肾腺增生或肿瘤的结果。在继发性醛固酮增多症中，醛固酮的过量产生是由心力衰竭和肾动脉疾病等外部条件引起的。
ENZO Aldosterone ELISA kit是一种比色竞争法酶免疫检测试剂盒，过夜 + 1 小时可以得到检测结果。
● 高灵敏度，可检测低至4.7 pg/ml的醛固酮
● 几乎不与其他类固醇反应
● 经过人和啮齿动物血清和血浆样本验证和测试
● 超越半定量Western blot分析的全定量检测
产品信息
产品货号 | ADI-900-173/ ADI-901-173 |
产品名称 | Aldosterone ELISA kit（醛固酮ELISA试剂盒） |
规格 | 96 wells/ 5x96 wells |
灵敏度 | 4.7 pg/ml |
检测范围 | 3.9 - 250 pg/ml |
检测时间 | Overnight + 1 hour |
样本种属 | Species independent |
样本类型 | plasma, serum, and urine |
保存温度 | Store all components at -20°C |
试剂盒组分 | DxS IgG Microtiter plate, Conjugate, Antibody, Assay buffer concentrate, Wash buffer concentrate, Standard, pNpp Substrate, Stop solution |
部分产品引用文献
1. A cardiac-null mutation of Prdm16 causes hypotension in mice with cardiac hypertrophy via increased nitric oxide synthase 1: J.O. Kang, et al.; PLoS One 17, e0267938 (2022)
2. Effects of amiloride on acetylcholine-dependent arterial vasodilation evolve over time in mice on a high salt diet: S.M. Mutchler, et al.; Physiol. Rep. 10, e15255 (2022)
3. Low-salt diet increases mRNA expression of aldosterone-regulated transporters in the intermediate portion of the endolymphatic sac: A. Matsubara, et al.; Pflugers Arch. (2022)
4. The microbiota-gut-kidney axis mediates host osmoregulation in a small desert mammal: Z. Nouri, et al.; NPJ Biofilms Microbiomes 8, 16 (2022)
5. The prognostic importance of the angiotensin II/angiotensin-(1–7) ratio in patients with SARS-CoV-2 infection: L.M. Amezcua-Guerra, et al.; Ther. Adv. Respir. Dis. 16, 17534666221122544 (2022)
6. Differential roles of VPS and RAAS in water homeostasis and a risk for kidney dysfunction in rats undergoing rapid fasting/dehydration with regular exercise: K. Hasegawa, et al.; Physiol. Rep. 9, e14670 (2021), Application(s): ELISA using rat plasma
7. Factors affecting the urinary aldosterone-to-creatinine ratio in healthy dogs and dogs with naturally occurring myxomatous mitral valve disease: A. Galizzi, et al.; BMC Vet. Res. 17, 15 (2021), Application(s): ELISA using dog urine
8. Loss of Soluble (Pro)renin Receptor Attenuates Angiotensin-II Induced Hypertension and Renal Injury: N. Ramkumar, et al.; Circ. Res. 129, 50 (2021), Application(s): Mouse urine and plasma
9. Metabolic syndrome during gestation and lactation: An important renal problem in dams. selenium renal clearance: F. Nogales, et al.; J. Trace Elem. Med. Biol. 64, 126709 (2021), Application(s): ELISA using rat serum
10. Renal interstitial fibroblasts coproduce erythropoietin and renin under anaemic conditions: K. Miyauchi, et al.; EBioMedicine 64, 103209 (2021), Application(s): ELISA using rat plasma
11. Salt-Sensitivity of Volume and Blood Pressure in a Mouse with Globally Reduced ENaC γ Subunit Expression: E.C. Ray, et al.; Am. J. Physiol. Renal Physiol. 321, F705 (2021)
12. Sex-dependent Effects of Nephron Ift88 Disruption on Blood Pressure, Renal Function and Cystogenesis: C. Hu, et al.; J. Am. Soc. Nephrol. 32, 2210 (2021)
13. The Effects of Beverage Intake after Exhaustive Exercise on Organ Damage, Inflammation and Oxidative Stress in Healthy Males: T. Tominaga, et al.; Antioxidants (Basel) 10, 866 (2021), Application(s): Aldosterone quantification on human plasma samples
14. The Expression of RAAS Key Receptors, Agtr2 and Bdkrb1, Is Downregulated at an Early Stage in a Rat Model of Wolfram Syndrome: M. Punapart, et al.; Genes (Basel) 12, 1717 (2021)
15. Differences in Renal BMAL1 Contribution to Na + Homeostasis and Blood Pressure Control in Male and Female Mice: G.R. Crislip, et al.; Am. J. Physiol. Renal Physiol. 318, 1463 (2020)
16. Kisspeptin deficiency leads to abnormal adrenal glands and excess steroid hormone secretion: A. Berthon, et al.; Hum. Mol. Genet. 2020, ddaa215 (2020)
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