TLR3(又名CD283)是一个胞内受体，可识别与病毒感染相关的双链RNA(dsRNA)分子模式。其中一个TLR3的配体，Poly(I:C)，是人工合成的dsRNA类似物。TLR3信号通路不依赖于MyD88，而是通过接头蛋白TRIF(包含TIR结构域的接头蛋白，可诱导IFN-β产生)发挥作用。IRF3(干扰素调节因子3)被磷酸化后导致IFN-β(β干扰素)产生，进一步活化ISRE(干扰素激活反应元件)。另外，TLR3信号通路的激活也可导致AP-1和NF-kB等转录因子入核，促进一些炎症因子的释放。
TLR3激动剂相关产品：
PRODUCT | ORIGIN/DESCRIPTION | GRADE* | WORKING CONCENTRATION | QTY | CATALOG CODE |
TLR LIGANDS |
TLR3 Agonists |
Poly(A:U) | Polyadenylic-polyuridylic acid | TLR2 -/ TLR4 - | 300 ng- 100 µg/ml | 10 mg | tlrl-pau |
Poly(I:C) (HMW) | Polyinosine-polycytidylic acid High molecular weight (1.5-8 kb) | TLR2 -/ TLR4 - | 30 ng - 10 µg/ml | 10 mg 50 mg | tlrl-pic tlrl-pic-5 |
Poly(I:C) (HMW) Biotin | Biotinylated poly(I:C) (HMW) | TLR2 -/ TLR4 - | 30 ng - 10 µg/ml | 10 µg | tlrl-picb |
Poly(I:C) (HMW) Fluorescein | Fluorescein-labeled poly(I:C) (HMW) | TLR2 -/ TLR4 - | 10 ng - 10 µg/ml | 10 µg | tlrl-picf |
Poly(I:C) (HMW) Rhodamine | Rhodamine-labeled poly(I:C) (HMW) | TLR2 -/ TLR4 - | 10 ng - 10 µg/ml | 10 µg | tlrl-picr |
PRR Ligands
PRODUCT | ORIGIN/DESCRIPTION | GRADE* | WORKING CONCENTRATION | QTY | CATALOG CODE |
TLR3 Agonists |
Poly(I:C) (HMW) VacciGrade™ | Preclinical grade poly(I:C) (HMW) | VacciGrade™ | 10 µg - 100 µg/mouse | 10 mg | vac-pic |
Poly(I:C) (LMW) | Polyinosine-polycytidylic acid Low molecular weight (0.2-1 kb) | TLR2 - /TLR4 - | 30 ng - 10 µg/ml | 25 mg 250 mg | tlrl-picw tlrl-picw-250 |
Poly(I:C) (LMW) Rhodamine | Rhodamine-labeled poly(I:C) (LMW) | TLR2 - /TLR4 - | 100 ng - 10 µg/ml | 10 µg | tlrl-piwr |
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