合成生物学的快速发展激发了人们对能够诊断和治疗疾病的工程微生物的兴趣。然而,设计检测动态疾病相关生物标志物的细菌,然后进行驱动治疗仍然很困难。最近,华东理工大学的研究团队在期刊《Cell Host & Microbe》(IF=31.316)上发表题为“Biomarker-responsive engineered probiotic diagnoses, records, and ameliorates inflammatory bowel disease in mice.”的文章,他们开发了一种工程益生菌,它可以非侵入性地实时监测和记录炎症性肠病(inflammatory bowel disease,IBD)的发生和发展,并可以通过一种自我调节的机制来响应这些生物标志物,从而释放治疗药物。这些用于诊断和治疗的智能响应细菌(i-ROBOT)由大肠杆菌Nissle 1917组成,该细菌通过激活碱基编辑系统来产生可遗传的基因组DNA序列并产生比色信号,从而对炎症标记物硫代硫酸盐的水平做出响应。硫代硫酸盐的波动也驱动免疫调节剂AvCystatin的可调释放。给患有结肠炎的小鼠口服i-ROBOT,在处理过的粪便和结肠样品中产生分子记录信号,并有效改善疾病。i-ROBOT为胃肠和其他代谢疾病提供了一个有前景的设计思路。
本文中使用了欣博盛Human IL-10和IL-12/23 p40 ELISA kits检测了细胞培养液上清样本中这些细胞因子的含量。
1.文章题目:Biomarker-responsive engineered probiotic diagnoses, records, and ameliorates inflammatory bowel disease in mice.
期 刊:Cell Host & Microbe(影响因子:31.316)
发表时间:27 December 2022
作 者:Zou Z P, Du Y, Fang T T, et al.
作者单位:华东理工大学
使用产品:Human IL-10 and IL-12/23 p40 ELISA kits
https://www.sciencedirect.com/science/article/abs/pii/S1931312822005765
2.文章题目:Targeting the transcription factor HES1 by L-menthol restores protein phosphatase 6 in keratinocytes in models of psoriasis.
期 刊:Nature Communications(影响因子:17.694)
发表时间:19 December 2022
作 者:Wang Z, Sun Y, Lou F, et al.
作者单位:上海交通大学
使用产品:Mouse IL-6 and TNF-α ELISA kits
样本类型:皮肤组织
https://pubmed.ncbi.nlm.nih.gov/36535970/
3.文章题目:Epigenetic reprogramming of carrier free photodynamic modulator to activate tumor immunotherapy by EZH2 inhibition.
期 刊:Biomaterials(影响因子:15.304)
发表时间:7 December 2022
作 者:Zhao L, Rao X, Huang C, et al.
作者单位:广州医科大学
使用产品:Mouse CXCL10 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/36502580/
4.文章题目:A cyclic heptapeptide-based hydrogel boosts the healing of chronic skin wounds in diabetic mice and patients.
期 刊:NPG Asia Materials(影响因子:10.761)
发表时间:23 December 2022
作 者:Fu Z, Sun H, Wu Y, et al.
作者单位:昆明医科大学
使用产品:Mouse TGF-β1 and TNF-α ELISA kits
https://www.nature.com/articles/s41427-022-00444-x
5.文章题目:Structural characterization and immunomodulatory activity of an exopolysaccharide from marine-derived Aspergillus versicolor SCAU141.
期 刊:International Journal of Biological Macromolecules(影响因子:8.025)
发表时间:17 December 2022
作 者:Wu K, Li Y, Lin Y, et al.
作者单位:华南农业大学
使用产品:Mouse IL-6 and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36535356/
6.文章题目:Involvement of gut-brain communication in arsenite-induced neurobehavioral impairments in adult male mice.
期 刊:Ecotoxicology and Environmental Safety(影响因子:7.129)
发表时间:9 December 2022
作 者:Lu Z, Wang F, Xia Y, et al.
作者单位:重庆医科大学
使用产品:Mouse TNF-α ELISA kit
样本类型:肠和脑组织
https://pubmed.ncbi.nlm.nih.gov/36508802/
7.文章题目:Perfluorooctane sulfonate promotes atherosclerosis by modulating M1 polarization of macrophages through the NF-κB pathway.
期 刊:Ecotoxicology and Environmental Safety(影响因子:7.129)
发表时间:10 December 2022
作 者:Wang D, Tan Z, Yang J, et al.
作者单位:河北医科大学
使用产品:Mouse IL-1β, IL-6 and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36512850/
8.文章题目:Glucagon-like Peptide 1 Receptor Activation Inhibits Microglial Pyroptosis via Promoting Mitophagy to Alleviate Depression-like Behaviors in Diabetic Mice.
期 刊:Nutrients(影响因子:6.706)
发表时间:21 December 2022
作 者:Yang F, Wang X, Qi J, et al.
作者单位:第四军医大学
使用产品:Mouse IL-1β ELISA kits
https://www.mdpi.com/2072-6643/15/1/38
9.文章题目:Triptolide leads to hepatic intolerance to exogenous lipopolysaccharide and natural-killer-cell mediated hepatocellular damage by inhibiting MHC class I molecules.
期 刊:Phytomedicine(影响因子:6.656)
发表时间:20 December 2022
作 者:Zhang H, Yuan Z, Wang J, et al.
作者单位:中国药科大学
使用产品:Mouse IFN-γ ELSIA kit
https://www.sciencedirect.com/science/article/pii/S0944711322007085
10.文章题目:Red raspberry supplementation mitigates alcohol-induced liver injury associated with gut microbiota alteration and intestinal barrier dysfunction in mice.
期 刊:Food & Function(影响因子:6.317)
发表时间:5 December 2022
作 者:Zogona D, Zongo A W S, Elkhedir A E, et al.
作者单位:南开大学
使用产品:Mouse IL-1β, IL-6 and TNF-α ELISA kits
https://pubs.rsc.org/en/content/articlehtml/2022/fo/d2fo03245g
11文章题目:evalsuation of the potential anti-soybean allergic activity of different forms of Lactobacillus delbrueckii subsp. bulgaricus based on cell model in vitro.
期 刊:Food & Function(影响因子:6.317)
发表时间:6 December 2022
作 者:Zhang M, Lu Q, Bai J, et al.
作者单位:南昌大学
使用产品:Human IL-6, IL-8, TNF-α and mouce IFN-γ, IL-4, IL-10 ELISA kits
https://pubs.rsc.org/en/content/articlehtml/2022/fo/d2fo02189g
12.文章题目:Garlic-derived Exosomes Carrying miR-396e Shapes Macrophage Metabolic Reprograming to Mitigate the Inflammatory Response in Obese Adipose Tissue.
期 刊:The Journal of Nutritional Biochemistry(影响因子:6.117)
发表时间:8 December 2022
作 者:Bian Y, Li W, Jiang X, et al.
作者单位:重庆理工大学
使用产品:Mouse TNF-α, IL-6 and IL-10 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36496060/
13.文章题目:The Anti-Photoaging Activity of Peptides from Pinctada martensii Meat.
期 刊:Marine Drugs(影响因子:6.085)
发表时间:8 December 2022
作 者:Wei M, Qiu H, Zhou J, et al.
作者单位:华南理工大学食品科学与工程学院
使用产品:Human MMP-1 and MMP-3 ELISA kits
https://www.mdpi.com/article/10.3390/md20120770
14.文章题目:Oryzanol Ameliorates DSS-Stimulated Gut Barrier Damage via Targeting the Gut Microbiota Accompanied by the TLR4/NF-κB/NLRP3 Cascade Response In Vivo.
期 刊:Journal of Agricultural and Food Chemistry(影响因子:5.895)
发表时间:6 December 2022
作 者:Xia X, Lin H, Luo F, et al.
作者单位:中南林业科技大学
使用产品:Rat TNF-α, IL-6, and IL-1β ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36474430/
15.文章题目:Effect of Structural Targeted Modifications on the Potential Allergenicity of Peanut Allergen Ara h 2.
期 刊:Journal of Agricultural and Food Chemistry(影响因子:5.895)
发表时间:27 December 2022
作 者:Zhou X, Ren L, Zhang Y, et al.
作者单位:南昌大学
使用产品:Mouse MCP-1 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/36574959/
16.文章题目:Diverse Galactooligosaccharides Differentially Reduce LPS-Induced Inflammation in Macrophages.
期 刊:Foods(影响因子:5.561)
发表时间:8 December 2022
作 者:Sun C, Hao B, Pang D, et al.
作者单位:广东省农业科学院蚕桑农业食品研究所
使用产品:Mouse IL-1β, IL-6 and TNF-α ELISA kits
https://www.mdpi.com/article/10.3390/foods11243973
17.文章题目:Novel Pectic Polysaccharides Isolated from Immature Honey Pomelo Fruit with High Immunomodulatory Activity.
期 刊:Molecules(影响因子:4.927)
发表时间:5 December 2022
作 者:Hou T, Guo S, Liu Z, et al.
作者单位:华南农业大学
使用产品:Mouse IL-6 and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36500662/
18.文章题目:Acetyl-CoA Carboxylase (ACC) Inhibitor, CP640186, Effectively Inhibited Dengue Virus (DENV) Infection via Regulating ACC Phosphorylation.
期 刊:Molecules(影响因子:4.927)
发表时间:5 December 2022
作 者:Wu W, Chen R, Wan Y, et al.
作者单位:中山大学中山眼科中心
使用产品:Mouse IFN-β ELISA kit
https://pubmed.ncbi.nlm.nih.gov/36500675/
19.文章题目:Differential Foreign Body Reactions between Branched and Linear Glucomannan Scaffolds.
期 刊:Journal of Functional Biomaterials(影响因子:4.901)
发表时间:11 December 2022
作 者:Li Y, Liu Y, Campos de Souza S, et al.
作者单位:澳门大学
使用产品:Mouse IL-1β ELISA kit
https://www.mdpi.com/2000288
20.文章题目:Non–small cell lung cancer-derived exosomes promote proliferation, phagocytosis, and secretion of microglia via exosomal microRNA in the metastatic microenvironment.
期 刊:Translational Oncology(影响因子:4.803)
发表时间:1 December 2022
作 者:Chen P, Li Y, Liu R, et al.
作者单位:华中科技大学同济医学院附属同济医院
使用产品:Mouse IL-6 and IL-8 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36463825/
21.文章题目:Activation of KLF6 by titanate nanofibers and regulatory roles of KLF6 on ATF3 in the endothelial monolayer and mouse aortas.
期 刊:Molecular Omics(影响因子:4.212)
发表时间:20 December 2022
作 者:Song F, Li S, Dai X, et al.
作者单位:南华大学
使用产品:Mouse MCP-1 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36538054/
22.文章题目:Synergism of TNF-α and IFN-β triggers human airway epithelial cells death by apoptosis and pyroptosis.
期 刊:Molecular Immunology(影响因子:4.174)
发表时间:9 December 2022
作 者:Sun R, Jiang K, Zeng C, et al.
作者单位:广州医科大学
使用产品:Human IL-1β ELISA kit
https://pubmed.ncbi.nlm.nih.gov/36508750/
23.文章题目:Inflammatory and pathological changes in Escherichia coli infected mice.
期 刊:Heliyon(影响因子:3.776)
发表时间:24 December 2022
作 者:Long N, Deng J, Qiu M, et al.
作者单位:成都医学院
使用产品:Mouse IL-1β, IL-6 and TNF-α ELISA kits
https://www.sciencedirect.com/science/article/pii/S240584402203821X
24.文章题目:Pmorf0222, a Virulence Factor in Pasteurella multocida, Activates Nuclear Factor Kappa B and Mitogen-Activated Protein Kinase via Toll-Like Receptor 1/2.
期 刊:Infection and Immunity(影响因子:3.609)
发表时间:21 December 2022
作 者:Xu T, Zheng Y, Liu B, et al.
作者单位:中国农业科学院哈尔滨兽医研究所
使用产品:Mouse IL-1β and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36541752/
25.文章题目:Mucosal immune responses induced by oral administration of recombinant Lactococcus lactis expressing the S1 protein of PDCoV.
期 刊:Virology(影响因子:3.513)
发表时间:26 December 2022
作 者:Zhai K, Zhang Z, Liu X, et al.
作者单位:中国农业科学院兰州兽医研究所
使用产品:Mouse IFN-γ, IL-2, IL-4, and IL-17 ELISA kits
https://www.sciencedirect.com/science/article/abs/pii/S0042682222002215
26.文章题目:Development of a serum-free culture method for endothelial cells of stria vascularis and their pro-inflammatory secretome changes induced by oxidative stress.
期 刊:Clinical and Experimental Otorhinolaryngology(影响因子:3.34)
发表时间:12 December 2022
作 者:Yi Y, Wang X R, Chen H T, et al.
作者单位:中山大学附属第一医院
使用产品:Mouse IL-1β, IL-6 and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36510681/
27.文章题目:Gab1 overexpression alleviates doxorubicin-induced cardiac oxidative stress, inflammation, and apoptosis through PI3K/Akt signaling pathway.
期 刊:Journal of Cardiovascular Pharmacology(影响因子:3.271)
发表时间:1 December 2022
作 者:Zhang Z, Shen C, Wu N, et al.
作者单位:宁波市第一医院
使用产品:Mouse TNF-α, IL-6 and IL-1β ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35856909/
28.文章题目:Janus kinase inhibitor Tofacitinib alleviated acute hepatitis induced by lipopolysaccharide/D-galactosamine in mice.
期 刊:Molecular Biology Reports(影响因子:2.742)
发表时间:12 December 2022
作 者:Zhang X, Lin L, Li L, et al.
作者单位:重庆医科大学
使用产品:Mouse IL-6 and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36507969/
29.文章题目:Shegan Mahuang Decoction May Reduce Airway Inflammation in Neutrophilic Asthmatic Mice by Improving the Mitochondrial Function of Bronchoalveolar Lavage Fluid Exosomes.
期 刊:Evidence-Based Complementary and Alternative Medicine(影响因子:2.65)
发表时间:19 December 2022
作 者:Lu H, Fu Z, Chen X, et al.
作者单位:重庆医科大学
使用产品:Mouse IL-4, IL-13, IL-33, and TGF-β ELISA kits
样本类型:肺泡灌洗液
https://www.hindawi.com/journals/ecam/2022/2477510/
30.文章题目:Lycium barbarum polysaccharide ameliorates radiation-induced brain injury by regulating gut microbiota.
期 刊:Journal of Traditional Chinese Medical Sciences(影响因子:2.547)
发表时间:2 December 2022
作 者:Hu J, Wang C, Li Q, et al.
作者单位:河南大学药学院
使用产品:Mouse TNF-α ELISA kit
https://www.sciencedirect.com/science/article/pii/S2095754822001107
31.文章题目:Manganese and the cGAS–STING Pathway in Infectious Mononucleosis Caused by Epstein-Barr Virus Infection.
期 刊:Viral Immunology(影响因子:2.175)
发表时间:9 December 2022
作 者:Shi J, Li Y, Zhang D, et al.
作者单位:苏州大学附属儿童医院
使用产品:Mouse IFN-α and IFN-β ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36493365/
32.文章题目:Human beta-defensin 1 circulating level and gene polymorphism in non-segmental vitiligo Egyptian patients.
期 刊:Anais Brasileiros de Dermatologia(影响因子:2.113)
发表时间:17 December 2022
作 者:Farag A G A, Shoeib M A A M, Sleem A S, et al.
作者单位:埃及Shebin EL-koum Menoufia大学
使用产品:Human β-Defensin-1 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/36535830/
33.文章题目:Expression and diagnostic value of miR-142-5p and miR-155-5p in the serum of children with allergic rhinitis.
期 刊:International Journal of Pediatric Otorhinolaryngology(影响因子:1.626)
发表时间:19 December 2022
作 者:Liu H, Ma G, Xing E, et al.
作者单位:承德医科大学附属医院
使用产品:Human IL-4 ELISA kit
https://www.sciencedirect.com/science/article/abs/pii/S016558762200386X
34.文章题目:Dexmedetomidine alleviates intestinal barrier dysfunction and inflammatory response in mice via suppressing TLR4/MyD88/NF-κB signaling in an experimental model of ulcerative colitis.
期 刊:Folia Histochemica et Cytobiologica(影响因子:1.49)
发表时间:9 December 2022
作 者:Ye X, Xu H, Xu Y.
作者单位:复旦大学附属金山医院
使用产品:Mouse IL-1β, IL-6 and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36504132/
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