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Ganglioseside GM1 . sodium salt (bovine brain)
品牌： Adipogen
产品货号： AG-CN2-9000-M001
规格： 1 mg

报价：
折后价：

数量： - +
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
  • 产品名称:
    Ganglioseside GM1 . sodium salt (bovine brain)
  • 别名:
    GM1 . Na; Monosialoganglioseside GM1 . Na
  • 产品描述:
    Gangliosesides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosesides has been linked to several diseases. Ganglioseside GM1 is a major sialoglycolipid of neuronal membranes that modulates calcium homeostasis and which is important for neuronal plasticity and repair mechanisms. It binds to cholera toxin B subunit, resulting in stimulation of adenylyl cyclase in a wide variety of cell types. After cholera toxin binds to membrane associated Monosialoganglioseside GM1, the A subunit of cholera toxin is translocated to the cell interior, where it catalyzes the ADP ribosylation of the membrane associated Gs subunit of adenylyl cyclase. In addition, binding of cholera toxin to monosialoganglioseside GM1 causes translocations of NF-kappaB and activation of dendritic cells. E. coli heat-labile enterotoxin (LT) is structurally and functionally similar to cholera toxin and binds GM1 as well. GM1 has also been shown to improve Parkinson's disease symptoms and slow it's progression.
  • 反应种属:
  • 宿主来源:
    Isolated from bovine brain.
  • 实验应用:
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  • 阳性对照:
  • 保存温度:
    -20°C
  • 运输温度:
    Ambient
  • 细胞定位:
  • 预期分子量:
    1545.8 . 23.0 (calculated on sphingosine C18:1 and stearic acid)
  • 产品形式:
    solid
  • 存储溶液:
    Lyophilized.
  • 有效期:
    Stable for at least 2 years after receipt when stored at -20°C.
  • 产地:
    瑞士
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  • 样本类型:
    Lyophilized.
  • 产品特点:
  • 纯度:
    >98% (TLC)
  • 生物活性:
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  • CAS号:
    37758-47-7
  • 分子式:
    C73H130N3O31 . Na
  • 溶解度:
  • PubChem CID:
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