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Periosestin (mouse) ELISA Kit
品牌： Adipogen
产品货号： AG-45B-0005-KI01
规格： 96 wells

报价：
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数量： - +
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
  • 产品名称:
    Periosestin (mouse) ELISA Kit
  • 别名:
    Osteoblast-specific Factor 2; OSF-2; Postn
  • 产品描述:
    Periosestin is a 90-kDa matricellular protein that consists of a typical signal sequence, followed by a cysteine-rich region, an EMI domain (protein-protein interactions), four tandem fasciclin-like domains that are responsible for integrin binding, and a C-terminal region. Periosestin was originally isolated as an osteoblast-specific factor that functions as a cell adhesion molecule for pre-osteoblasts and in osteoblast recruitment, attachment and spreading. Periosestin is also involved in many fundamental biological processes such as cell proliferation, cell invasion and angiogenesis. Periosestin expression is increased by both transforming growth factor beta1 (TGF-beta1) and bone morphogenetic protein 2 (BMP-2). Changes in periosestin expression are commonly detected in various cancers and pre-cancerous conditions, and periosestin may be involved in regulating cancer cell activities that contribute to tumorigenesis, cancer progression and metastasis. Periosestin up-regulation in cancers usually correlates with aggressiveness and/or poor survival. Periosestin has shown to be involved in many aspects of allergic inflammation, such as eosinophil recruitment, airway remodeling, development of a Th2 phenotype and increased expression of inflammatory mediators. It is evalsuated as a biomarker for bronchial asthma and airway inflammation.
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  • 保存温度:
    +4°C
  • 运输温度:
    BLUE ICE
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  • 有效期:
    12 months after the day of manufacturing. See expiry date on ELISA Kit box.
  • 产地:
    瑞士
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