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Asprosin (human) ELISA Kit
品牌： Adipogen
产品货号： AG-45B-0010-KI01
规格： 96 wells

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数量： - +
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
  • 产品名称:
    Asprosin (human) ELISA Kit
  • 别名:
    Fibrillin-1 C-terminal Cleavage Product; FBN1 C Terminal Cleavage Product
  • 产品描述:
    Asprosin is a new fasting-induced protein hormone that targets the liver to increase plasma glucose levels. Asprosin is the C-terminal cleavage product of the protein Fibrillin-1. Asprosin is secreted from white adipose tissue and increases hepatic glucose production by using cAMP as a second messenger, leading to activation of protein Kinase A. Reduction of asprosin levels protects against metabolic syndrome-associated hyperinsulinism. Asprosin may act as a circulating hunger signal. Indeed, peripherally injected recombinant asprosin can cross the blood-brain barrier and intracerebroventricular (i.c.v.) injection of recombinant asprosin stimulated appetite in wild-type mice, indicating a central mechanism of action. Loss of asprosin in mice and human leads to decreased fat mass and body weight and hypophagia. Mice are also completely protected from the development of diet-induced obesity. Asprosin works by stimulating the orexigenic AgRP+ (Agouti-related neuropeptide) neurons via a cAMP-dependent pathway and by inhibiting the anorexigenic neurons POMC+ (pro-opiomelanocortin) neurons in a GABA-dependent manner. Mutation in asprosin in human leads to the pattern of metabolic dysregulation, including partial lipodsystrophy, accompanied by reduced plasma insulin. Due to its key role in food regulation, asprosin function could serve as a potentially unique therapeutic target against obesity, diabetes or metabolic diseases.
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  • 保存温度:
    +4°C
  • 运输温度:
    BLUE ICE
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  • 有效期:
    12 months after the day of manufacturing. See expiry date on ELISA Kit box.
  • 产地:
    瑞士
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