瘦素(Leptin)是由ob基因编码、在脂肪组织中生成的一种脂肪代谢调控产物，在代谢和调控体重等方面发挥重要作用。它通过下丘脑中的瘦素受体发出信号，降低食欲，增加能量消耗。在外周组织中，瘦素能拮抗胰岛素信号传导，增加脂肪酸氧化，减少胰岛β细胞的胰岛素分泌，并促进生育。它在脂肪细胞中的表达可以被其他脂肪因子如IL-6（刺激）和TNF-α（抑制）以旁分泌方式调节。瘦素缺乏的小鼠表现出严重的胰岛素抵抗、肥胖和生育能力下降，所有这些都可以通过外源性瘦素给药而逆转。
● 无边缘效应：所有孵育步骤在常温下进行消除了37°C下蒸发的风险
● 检测范围广：易于定量检测高水平和低水平瘦素
● 方便：所有试剂保存在4°C
● 快速：仅需3小时就可获得39个样本的重复结果
● 预包被板和即用型试剂为您节省实验时间
产品信息
产品货号 | ADI-900-015A |
产品名称 | Leptin (rat), ELISA kit（大鼠瘦素ELISA试剂盒） |
规格 | 96 wells |
灵敏度 | 67.2 pg/ml |
检测范围 | 100- 6,400 pg/ml |
检测时间 | 3 hours |
样本种属 | Rat |
样本类型 | culture supernatants, plasma, and serum |
保存温度 | +4°C |
试剂盒组分 | Microtiter plate, Standard, Antibody, Conjugate, Assay buffer 28, TMB Substrate, Stop solution 2, Wash buffer concentrate |
部分产品引用文献
1. Altered motor, anxiety-related and attentional task performance at baseline associate with multiple gene copies of the vesicular acetylcholine transporter and related protein overexpression in ChAT::Cre+ rats: C.P. Mantanona, et al.; Brain Struct. Funct. 224, 3095 (2019)
2. Long-term feeding of red algae (Gelidium amansii) ameliorates glucose and lipid metabolism in a high fructose diet-impaired glucose tolerance rat model: H.C. Liu, et al.; J. Food Drug Anal. 25, 543 (2017), Application(s): Determination of leptin, rat plasma
3. Melatonin supplementation plus exercise behavior ameliorate insulin resistance, hypertension and fatigue in a rat model of type 2 diabetes mellitus: M.M. Rahman, et al.; Biomed. Pharmacother. 92, 606 (2017)
4. Effect of Intermittent Hypoxia on Arcuate Nucleus in the Leptin-Deficient Rat: J. Ciriello, et al.; Neurosci. Lett. 626, 112 (2016), Application(s): Measured leptin levels in rat aqueous plasma phase
5. Neonatal treatment with scopolamine butylbromide prevents metabolic dysfunction in male rats: A. Malta, et al.; Sci. Rep. 6, 30745 (2016), Application(s): Leptin level quantification
6. Impact of prenatal exposure to obesogenic environment on later-life brown and white adipocytes and liver outcomes: L. Bezpalko, et al.; Proc. Shevchenko Sci. Soc. Medicine 41, 33 (2015), Application(s): ELISA using rat serum
7. Lactobionic acid reduces body weight gain in diet-induced obese rats by targeted inhibition of galectin-1: R. Mukherjee, et al.; Biochem. Biophys. Res. Commun. 463, 1311 (2015), Application(s): ELISA using rat plasma
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