细胞表面受体TLR5可识别鞭毛蛋白，后者是革兰氏阳性菌和革兰氏阴性菌表面鞭毛丝的主要成份。TLR5活化后通过MyD88信号通路促进一些炎症因子的释放。TLR5通过形成同源二聚体来激活炎症信号通路，这显示它可能是唯一参与鞭毛蛋白识别的TLR分子。
TLR5激动剂产品如下：
PRODUCT | ORIGIN/DESCRIPTION | GRADE* | WORKING CONCENTRATION | QTY | CATALOG CODE |
TLR5 Agonists |
FLA-BS | Standard flagellin from B. subtilis - 10% pure | TLR2 + /TLR4 + | 10 ng - 10 µg/ml | 100 µg | tlrl-bsfla |
FLA-BS Ultrapure | Ultrapure flagellin from B. subtilis - >95% pure | TLR2 - /TLR4 - | 1 ng - 1 µg/ml | 50 µg | tlrl-pbsfla |
FLA-PA Ultrapure | Ultrapure flagellin from P. aeruginosa - >95% pure | TLR2 - /TLR4 - | 1 ng - 1 µg/ml | 50 µg | tlrl-pafla |
FLA-ST | Standard flagellin from S. typhimurium - 10% pure | TLR2 + /TLR4 + | 10 ng - 10 µg/ml | 100 µg | tlrl-stfla |
FLA-ST Ultrapure | Ultrapure flagellin from S. typhimurium - >95% pure | TLR2 - /TLR4 - | 10 - 100 ng/ml | 10 µg 50 µg | tlrl-epstfla tlrl-epstfla-5 |
RecFLA-ST | Recombinant flagellin from S. typhimurium | TLR2 - /TLR4 - | 10 - 100 ng/ml | 50 µg 10 µg | tlrl-flic-50 tlrl-flic-10 |
Flagellin Flic VacciGrade™ | Preclinical grade RecFLA-ST | VacciGrade™ | 1 - 10 µg/mouse | 50 µg | vac-fla |
TLR5 Antagonist |
hTLR5-Fc | Soluble ectodomain of TLR5 | TLR2 - /TLR4 - | 10 ng- 1 µg/ml | 50 µg | fc-htlr5 |
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